Comparison of eye lens and hand skin exposures during handling 18F, 11C and 68Ga radiopharmaceuticals

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F19%3A00334285" target="_blank" >RIV/68407700:21460/19:00334285 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00259-019-04486-2" target="_blank" >http://dx.doi.org/10.1007/s00259-019-04486-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00259-019-04486-2" target="_blank" >10.1007/s00259-019-04486-2</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Comparison of eye lens and hand skin exposures during handling 18F, 11C and 68Ga radiopharmaceuticals

Popis výsledku v původním jazyce

The aim of the paper is to point out the importance of controlling the compliance with radiation protection requirements in PET workplaces for newly introduced positron radiopharmaceuticals where routine procedure applicable to handling of 18F, 11C and 68Ga may result in higher skin and/or eye lens exposure. In nuclear medicine, a radiopharmaceutical is routinely administered to a patient via a cannula. The comparison of the exposure due to gamma photons and positrons of hand holding the infusion tube leading into the cannula with radiopharmaceutical solutions 18F, 11C and 68Ga is simulated by the MC using a hand voxel phantom. In the same administration of the radiopharmaceutical, the administering person is inclined above the injection site and observes the infusion tube filling with the radiopharmaceutical while exposing the eyes to the gamma radiation and the positrons penetrating the infusion tube. The equivalent dose of the eye lens in the head voxel phantom is compared to the Hp(3) calculations of the personal TLD dosimeter placed on the chest of the MIRD chest phantom for the same irradiation geometry. MC with the phantom of the hand holding the infusion tube showed that when replacing the 18F radiopharmaceutical with 11C, the skin irradiation on the hands is increased by a factor of 2. The confusion of the 18F radiopharmaceutical 68Ga is more prominent, with a 4-fold increase in skin irradiation at the same actions hands. In the case of irradiation of the eye lens with an unshielded 68Ga radiopharmaceutical at a distance of 50 cm, Monte Carlo simulations showed that the equivalent dose is a factor of 2 higher than the Hp(3) value obtained by a personal chest dosimeter. The efficiency of radiation protection measures introduced when handling the 18F radiopharmaceuticals should be carefully checked when introducing 11C and 68Ga labelled radiopharmaceuticals

Název v anglickém jazyce

Comparison of eye lens and hand skin exposures during handling 18F, 11C and 68Ga radiopharmaceuticals

Popis výsledku anglicky

The aim of the paper is to point out the importance of controlling the compliance with radiation protection requirements in PET workplaces for newly introduced positron radiopharmaceuticals where routine procedure applicable to handling of 18F, 11C and 68Ga may result in higher skin and/or eye lens exposure. In nuclear medicine, a radiopharmaceutical is routinely administered to a patient via a cannula. The comparison of the exposure due to gamma photons and positrons of hand holding the infusion tube leading into the cannula with radiopharmaceutical solutions 18F, 11C and 68Ga is simulated by the MC using a hand voxel phantom. In the same administration of the radiopharmaceutical, the administering person is inclined above the injection site and observes the infusion tube filling with the radiopharmaceutical while exposing the eyes to the gamma radiation and the positrons penetrating the infusion tube. The equivalent dose of the eye lens in the head voxel phantom is compared to the Hp(3) calculations of the personal TLD dosimeter placed on the chest of the MIRD chest phantom for the same irradiation geometry. MC with the phantom of the hand holding the infusion tube showed that when replacing the 18F radiopharmaceutical with 11C, the skin irradiation on the hands is increased by a factor of 2. The confusion of the 18F radiopharmaceutical 68Ga is more prominent, with a 4-fold increase in skin irradiation at the same actions hands. In the case of irradiation of the eye lens with an unshielded 68Ga radiopharmaceutical at a distance of 50 cm, Monte Carlo simulations showed that the equivalent dose is a factor of 2 higher than the Hp(3) value obtained by a personal chest dosimeter. The efficiency of radiation protection measures introduced when handling the 18F radiopharmaceuticals should be carefully checked when introducing 11C and 68Ga labelled radiopharmaceuticals

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

30305 - Occupational health

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů