Maximal velocity and amplitude decrement angle: a novel parameter for finger tapping instrumental evaluation in Parkinson disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F19%3A00336270" target="_blank" >RIV/68407700:21460/19:00336270 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.gaitpost.2019.07.158" target="_blank" >http://dx.doi.org/10.1016/j.gaitpost.2019.07.158</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.gaitpost.2019.07.158" target="_blank" >10.1016/j.gaitpost.2019.07.158</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Maximal velocity and amplitude decrement angle: a novel parameter for finger tapping instrumental evaluation in Parkinson disease

Popis výsledku v původním jazyce

Maximal opening velocity and amplitude decrement in the finger tapping test (FT) are sensitive independent parameters measures of bradykinesa in Parkinson disease (PD). Whereas amplitude decrement characterizes the sequence effect [4], opening velocity corresponds to motor slowing. We included 55 PD patients (29 M, 26 F), mean age 65 (range 46–82) years, with mild PD, Hoehn & Yahr stage 2 (1-2.5) in their the best medication state and 59 (29 M, 26 F) normal controls (NC), mean age 66 (41-82). They performed the UPDRS-III item 23 FT with each hand twice. FT was independently blindly rated by two movement disorders specialists from video recordings (VT parameter). FT was assessed by a contactless 3D motion capture system Optitrack-V120 that measured the mutual distance of markers placed on the distal phalanx of the thumb and forefinger. The amplitude decrement angle (ADA), maximal opening velocity angle (OVA) and the combination of velocity and amplitude decrement angle (VADA) were computed from the 5th to 10th finger taps (see Figure). Four measurements (twice for each hand) were averaged for each parameter and mean; standard deviation was computed for PD and NC group OVA(-5.0o ± 3.4 o; -3.1o ± 1.9o); ADA(-4.3o ± 2.5o;-2.8o ± 1.3o); VADA(-9.3o ± 3.3o;-5.8o ± 1.8o); VT(-1.3o ± 0.5o; -0.9o ± 0.5o). There was a statistically significant difference between the groups in each parameter: OVA(p=2e-04, AUC=0.66); ADA(p=8e-05, AUC=0.70); VADA(p=3e-10, AUC=0.82); VT(p=3e-06, AUC=0.74). We conclude that the sequence effect characterized by amplitude decrement should be extended with velocity measurement for the diagnosis of PD.

Název v anglickém jazyce

Maximal velocity and amplitude decrement angle: a novel parameter for finger tapping instrumental evaluation in Parkinson disease

Popis výsledku anglicky

Maximal opening velocity and amplitude decrement in the finger tapping test (FT) are sensitive independent parameters measures of bradykinesa in Parkinson disease (PD). Whereas amplitude decrement characterizes the sequence effect [4], opening velocity corresponds to motor slowing. We included 55 PD patients (29 M, 26 F), mean age 65 (range 46–82) years, with mild PD, Hoehn & Yahr stage 2 (1-2.5) in their the best medication state and 59 (29 M, 26 F) normal controls (NC), mean age 66 (41-82). They performed the UPDRS-III item 23 FT with each hand twice. FT was independently blindly rated by two movement disorders specialists from video recordings (VT parameter). FT was assessed by a contactless 3D motion capture system Optitrack-V120 that measured the mutual distance of markers placed on the distal phalanx of the thumb and forefinger. The amplitude decrement angle (ADA), maximal opening velocity angle (OVA) and the combination of velocity and amplitude decrement angle (VADA) were computed from the 5th to 10th finger taps (see Figure). Four measurements (twice for each hand) were averaged for each parameter and mean; standard deviation was computed for PD and NC group OVA(-5.0o ± 3.4 o; -3.1o ± 1.9o); ADA(-4.3o ± 2.5o;-2.8o ± 1.3o); VADA(-9.3o ± 3.3o;-5.8o ± 1.8o); VT(-1.3o ± 0.5o; -0.9o ± 0.5o). There was a statistically significant difference between the groups in each parameter: OVA(p=2e-04, AUC=0.66); ADA(p=8e-05, AUC=0.70); VADA(p=3e-10, AUC=0.82); VT(p=3e-06, AUC=0.74). We conclude that the sequence effect characterized by amplitude decrement should be extended with velocity measurement for the diagnosis of PD.

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

20601 - Medical engineering

Projekt

<a href="/cs/project/NV16-28119A" target="_blank" >NV16-28119A: Analýza pohybových poruch pro studium mechanismů postižení u extrapyramidových onemocnění pomocí „motion capture“ kamerových systémů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů