Preventive Administration of Melatonin Attenuates Electrophysiological Consequences of Myocardial Ischemia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F20%3A00342559" target="_blank" >RIV/68407700:21460/20:00342559 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1007/s10517-020-04881-y" target="_blank" >https://doi.org/10.1007/s10517-020-04881-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10517-020-04881-y" target="_blank" >10.1007/s10517-020-04881-y</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Preventive Administration of Melatonin Attenuates Electrophysiological Consequences of Myocardial Ischemia

Popis výsledku v původním jazyce

The effect of preventive administration of melatonin on the arrhythmogenic substrate in the myocardium was studied in the rabbit model of acute ischemia/reperfusion in vivo. The animals treated with melatonin 60 min before ischemia induction had shorter median activation time compared to the control group (p=0.039), less pronounced shortening of repolarization durations in the ischemic zone during coronary occlusion (p=0.008), and more complete recovery of repolarization during reperfusion (p=0.027). In the melatonin group, the dispersion of repolarization was less than in the control group during both ischemic period (p=0.043) and reperfusion (p=0.038). Thus, preventive administration of melatonin mitigated the arrhythmogenic substrate in the heart under conditions of ischemia/reperfusion.

Název v anglickém jazyce

Preventive Administration of Melatonin Attenuates Electrophysiological Consequences of Myocardial Ischemia

Popis výsledku anglicky

The effect of preventive administration of melatonin on the arrhythmogenic substrate in the myocardium was studied in the rabbit model of acute ischemia/reperfusion in vivo. The animals treated with melatonin 60 min before ischemia induction had shorter median activation time compared to the control group (p=0.039), less pronounced shortening of repolarization durations in the ischemic zone during coronary occlusion (p=0.008), and more complete recovery of repolarization during reperfusion (p=0.027). In the melatonin group, the dispersion of repolarization was less than in the control group during both ischemic period (p=0.043) and reperfusion (p=0.038). Thus, preventive administration of melatonin mitigated the arrhythmogenic substrate in the heart under conditions of ischemia/reperfusion.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30109 - Pathology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bulletin of Experimental Biology and Medicine

ISSN

0007-4888

e-ISSN

1573-8221

Svazek periodika

169

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

4

Strana od-do

328-331

Kód UT WoS článku

000554849500003

EID výsledku v databázi Scopus

2-s2.0-85088815234