Functional Magnetic Resonance Imaging Following Epimacular and Internal Limiting Membrane Peeling - Ipsilateral and Contralateral Findings

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F20%3A00347852" target="_blank" >RIV/68407700:21460/20:00347852 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.5507/bp.2019.044" target="_blank" >https://doi.org/10.5507/bp.2019.044</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2019.044" target="_blank" >10.5507/bp.2019.044</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Functional Magnetic Resonance Imaging Following Epimacular and Internal Limiting Membrane Peeling - Ipsilateral and Contralateral Findings

Popis výsledku v původním jazyce

Purpose. The purpose of this study was to find out whether peeling of the epimacular membrane (EMM) and internal limiting membrane (ILM) for symptomatic lamellar macular hole (LMH), causes impairment of the visual cortex. Patients and Methods: This pilot study consisted of 8 eyes of 4 patients (2 females and 2 males), mean age 69.25 years (60-83 years), who underwent pars plana vitrectomy and EMM and ILM peeling in one eye for lamellar macular hole The second eye remained intact. The patients had no other ophthalmological or neurological disease. The control group consisted of 20 eyes of 10 healthy people (8 females and 2 males). mean age 52 years (34-65 years). In all of them, we performed functional magnetic resonance imaging (fMRI) of the brain to the visual paradigm (black and white chessboard of 25.8 x 16.2 degrees in size), as well as in patients 3-4 years following the surgery. For statistical processing, we used ANOVA and multiple regression for adjustment for the age of patients. Results: In all patients, we recorded a decrease in fMRI activity of the brain following stimulation of the eye in which surgical intervention was performed. The fMRI values using ANOVA (without adjustment for age) were significantly different between groups (P<0.001). Following adjustment for age and the use of multiple regression, the fMRI values in the operated eyes were lower by 4142.39 vs the control eyes. In the group of unoperated eyes, the fMRI values were lower by 2807.39 vs the control eyes. Therefore, the results did not differ very much from the results without adjustment.

Název v anglickém jazyce

Functional Magnetic Resonance Imaging Following Epimacular and Internal Limiting Membrane Peeling - Ipsilateral and Contralateral Findings

Popis výsledku anglicky

Purpose. The purpose of this study was to find out whether peeling of the epimacular membrane (EMM) and internal limiting membrane (ILM) for symptomatic lamellar macular hole (LMH), causes impairment of the visual cortex. Patients and Methods: This pilot study consisted of 8 eyes of 4 patients (2 females and 2 males), mean age 69.25 years (60-83 years), who underwent pars plana vitrectomy and EMM and ILM peeling in one eye for lamellar macular hole The second eye remained intact. The patients had no other ophthalmological or neurological disease. The control group consisted of 20 eyes of 10 healthy people (8 females and 2 males). mean age 52 years (34-65 years). In all of them, we performed functional magnetic resonance imaging (fMRI) of the brain to the visual paradigm (black and white chessboard of 25.8 x 16.2 degrees in size), as well as in patients 3-4 years following the surgery. For statistical processing, we used ANOVA and multiple regression for adjustment for the age of patients. Results: In all patients, we recorded a decrease in fMRI activity of the brain following stimulation of the eye in which surgical intervention was performed. The fMRI values using ANOVA (without adjustment for age) were significantly different between groups (P<0.001). Following adjustment for age and the use of multiple regression, the fMRI values in the operated eyes were lower by 4142.39 vs the control eyes. In the group of unoperated eyes, the fMRI values were lower by 2807.39 vs the control eyes. Therefore, the results did not differ very much from the results without adjustment.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30207 - Ophthalmology

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Papers

ISSN

1213-8118

e-ISSN

1804-7521

Svazek periodika

164

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

4

Strana od-do

273-276

Kód UT WoS článku

000595645600008

EID výsledku v databázi Scopus

2-s2.0-85091187902