Neuroprotection in glaucoma-electrophysiology

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F20%3A00347858" target="_blank" >RIV/68407700:21460/20:00347858 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.3892/etm.2020.8509" target="_blank" >https://doi.org/10.3892/etm.2020.8509</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3892/etm.2020.8509" target="_blank" >10.3892/etm.2020.8509</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Neuroprotection in glaucoma-electrophysiology

Popis výsledku v původním jazyce

Hypertensive glaucoma is defined as a group of diseases with progressive loss of the neuroretinal margin of the optic disc that causes characteristic degenerative optic neuropathy. The present study provided an updated summary of the physiology and pathology of neurotransmission in the visual path, with the focus on glaucoma. The results of positron emission tomography, functional magnetic resonance imaging and mainly electrophysiological methods demonstrated pathogenesis of nerve cell damage in the visual pathway. Based on these conclusions, neuroprotection in glaucoma was proposed. This consists mainly of the reduction of the intraocular pressure. It is followed by a decrease of glutamate in the synaptic cleft and blockade of its binding to the NMDA receptors. The supply of energy substrates to altered nerve cells is also indispensable. Therapy should be systemic due to impairment of the complete visual path.

Název v anglickém jazyce

Neuroprotection in glaucoma-electrophysiology

Popis výsledku anglicky

Hypertensive glaucoma is defined as a group of diseases with progressive loss of the neuroretinal margin of the optic disc that causes characteristic degenerative optic neuropathy. The present study provided an updated summary of the physiology and pathology of neurotransmission in the visual path, with the focus on glaucoma. The results of positron emission tomography, functional magnetic resonance imaging and mainly electrophysiological methods demonstrated pathogenesis of nerve cell damage in the visual pathway. Based on these conclusions, neuroprotection in glaucoma was proposed. This consists mainly of the reduction of the intraocular pressure. It is followed by a decrease of glutamate in the synaptic cleft and blockade of its binding to the NMDA receptors. The supply of energy substrates to altered nerve cells is also indispensable. Therapy should be systemic due to impairment of the complete visual path.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30207 - Ophthalmology

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

EXPERIMENTAL AND THERAPEUTIC MEDICINE

ISSN

1792-0981

e-ISSN

1792-1015

Svazek periodika

19

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GR - Řecká republika

Počet stran výsledku

5

Strana od-do

2401-2405

Kód UT WoS článku

000523637100001

EID výsledku v databázi Scopus

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