Discrete event simulation model for cost-effectiveness evaluation of screening for asymptomatic patients with lower extremity arterial disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F22%3A00358558" target="_blank" >RIV/68407700:21460/22:00358558 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.3390/ijerph191811792" target="_blank" >https://doi.org/10.3390/ijerph191811792</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijerph191811792" target="_blank" >10.3390/ijerph191811792</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Discrete event simulation model for cost-effectiveness evaluation of screening for asymptomatic patients with lower extremity arterial disease

Popis výsledku v původním jazyce

Lower limb ischemic disease (LEAD) affects a significant portion of the population, with most patients being asympto-matic. Patient screening is necessary because LEAD patients have an increased risk of occurrence other cardiovascular events and manifestations of disease in terms of leg symptoms such as intermittent claudication, critical limb ischemia or amputation. The aim of this work is to evaluate cost-effectiveness of screening using ABI diagnostics in asymptomatic patients and its impact on limb symptoms associated with LEAD. Discrete event simulation model was created for capturing lifetime costs and effects. Costs were calculated from the perspective of the health care payer and the effects were calculated as QALYs. The cost-effectiveness analysis was calculated to compare the ABI screening examination and the situation without such screening. The probabilistic sensitivity analysis and scenario analysis were calculated to evaluate the robustness of the results. In the basic setting, the screening intervention was a more expensive intervention at a cost of CZK 174,010, compared to CZK 70,177 for the strategy without screening. The benefits of screening were es-timated at 14.73 QALYs, and 14.46 QALYs without screening. The final ICER value of CZK 389,738 per QALY is below the willingness to pay threshold. The results of the simulated cost-effectiveness analysis suggest that screening using the ABI method is a cost-effective strategy. Likewise, the results of the probabilistic sensitivity analysis and of the scenario analysis are below the threshold of willingness to pay, thus confirming the robustness of the results.

Název v anglickém jazyce

Discrete event simulation model for cost-effectiveness evaluation of screening for asymptomatic patients with lower extremity arterial disease

Popis výsledku anglicky

Lower limb ischemic disease (LEAD) affects a significant portion of the population, with most patients being asympto-matic. Patient screening is necessary because LEAD patients have an increased risk of occurrence other cardiovascular events and manifestations of disease in terms of leg symptoms such as intermittent claudication, critical limb ischemia or amputation. The aim of this work is to evaluate cost-effectiveness of screening using ABI diagnostics in asymptomatic patients and its impact on limb symptoms associated with LEAD. Discrete event simulation model was created for capturing lifetime costs and effects. Costs were calculated from the perspective of the health care payer and the effects were calculated as QALYs. The cost-effectiveness analysis was calculated to compare the ABI screening examination and the situation without such screening. The probabilistic sensitivity analysis and scenario analysis were calculated to evaluate the robustness of the results. In the basic setting, the screening intervention was a more expensive intervention at a cost of CZK 174,010, compared to CZK 70,177 for the strategy without screening. The benefits of screening were es-timated at 14.73 QALYs, and 14.46 QALYs without screening. The final ICER value of CZK 389,738 per QALY is below the willingness to pay threshold. The results of the simulated cost-effectiveness analysis suggest that screening using the ABI method is a cost-effective strategy. Likewise, the results of the probabilistic sensitivity analysis and of the scenario analysis are below the threshold of willingness to pay, thus confirming the robustness of the results.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

50602 - Public administration

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Environmental Research and Public Health

ISSN

1661-7827

e-ISSN

1660-4601

Svazek periodika

19

Číslo periodika v rámci svazku

18

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

16

Strana od-do

—

Kód UT WoS článku

000858252500001

EID výsledku v databázi Scopus

2-s2.0-85138688463