Selective Monitoring of Beta and Gamma Exposure of Hands of DNM Workers Handling Radiopharmaceuticals

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F22%3A00359959" target="_blank" >RIV/68407700:21460/22:00359959 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/content/pdf/10.1007/s00259-022-05924-4.pdf" target="_blank" >https://link.springer.com/content/pdf/10.1007/s00259-022-05924-4.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Selective Monitoring of Beta and Gamma Exposure of Hands of DNM Workers Handling Radiopharmaceuticals

Popis výsledku v původním jazyce

The implementation of a new procedure at the Nuclear Medicine Department (NMD) may lead to exceeding the workers’ exposure reference level. At NMDs, for the assessment of local exposure of the skin on hands, the thermoluminescent dosimeters (TLDs) are typically used. They usually provide the overall gamma and beta skin exposure in terms of the total HP(0.07). The paper proposes a modified method based on a new design of a ring dosimeter for the selective measurement of local skin exposure. The intention of the paper is to demonstrate and verify this approach when handling 18F and 177Lu-labeled radiopharmaceuticals. A pair of TLD MCP-7 and TLD MCP-Ns was used to selectively determine the local skin exposure in terms of HP(0.07). The detectors were made of the same material but differed in their thicknesses, which resulted in the different absorption of beta radiation. The MCP-Ns dosimeter has a thin sensitive layer in which the self-absorption of beta radiation is negligible, and thus, it has the same response to the gamma and beta radiation. The response of the MCP-7 TLD and the MCP-Ns TLD MCP-Ns dosimeters to the radiation emitted by 18F and 177Lu radionuclides were calculated using the Monte Carlo Code MCNPX. Using Monte Carlo simulations, the responses of a pair of TLD MCP-7 and TLD MCP-Ns dosimeters of beta-gamma finger Exposure of handmonitors located on the second finger point and at the root of the phantom index finger of soft tissue equivalent material have been determined. At the same time, the finger monitors were positioned in places as close as possible to the expected maximum skin exposure as long as they have not interfered with the handling of the radiopharmaceuticals. The beta-gamma selective ring monitor was tested at the NMD during the preparation of 18F and 177Lu-labeled radiopharmaceuticals. The new method and modified design of a finger monitor were introduced, and the first experiments were performed to measure local skin exposure on the hands corresponding to of HP(0.07) when handling 18F and 177Lu-labeled radiopharmaceuticals. The first results of monitoring with the proposed beta-gamma finger monitors have shown: - Relatively significant incidence of skin exposure due to beta particles when handling 177Lu-labeled therapeutic radiopharmaceuticals, and Increased sensitivity of beta-gamma finger monitors if they are placed on the second point of the index finger.

Název v anglickém jazyce

Selective Monitoring of Beta and Gamma Exposure of Hands of DNM Workers Handling Radiopharmaceuticals

Popis výsledku anglicky

The implementation of a new procedure at the Nuclear Medicine Department (NMD) may lead to exceeding the workers’ exposure reference level. At NMDs, for the assessment of local exposure of the skin on hands, the thermoluminescent dosimeters (TLDs) are typically used. They usually provide the overall gamma and beta skin exposure in terms of the total HP(0.07). The paper proposes a modified method based on a new design of a ring dosimeter for the selective measurement of local skin exposure. The intention of the paper is to demonstrate and verify this approach when handling 18F and 177Lu-labeled radiopharmaceuticals. A pair of TLD MCP-7 and TLD MCP-Ns was used to selectively determine the local skin exposure in terms of HP(0.07). The detectors were made of the same material but differed in their thicknesses, which resulted in the different absorption of beta radiation. The MCP-Ns dosimeter has a thin sensitive layer in which the self-absorption of beta radiation is negligible, and thus, it has the same response to the gamma and beta radiation. The response of the MCP-7 TLD and the MCP-Ns TLD MCP-Ns dosimeters to the radiation emitted by 18F and 177Lu radionuclides were calculated using the Monte Carlo Code MCNPX. Using Monte Carlo simulations, the responses of a pair of TLD MCP-7 and TLD MCP-Ns dosimeters of beta-gamma finger Exposure of handmonitors located on the second finger point and at the root of the phantom index finger of soft tissue equivalent material have been determined. At the same time, the finger monitors were positioned in places as close as possible to the expected maximum skin exposure as long as they have not interfered with the handling of the radiopharmaceuticals. The beta-gamma selective ring monitor was tested at the NMD during the preparation of 18F and 177Lu-labeled radiopharmaceuticals. The new method and modified design of a finger monitor were introduced, and the first experiments were performed to measure local skin exposure on the hands corresponding to of HP(0.07) when handling 18F and 177Lu-labeled radiopharmaceuticals. The first results of monitoring with the proposed beta-gamma finger monitors have shown: - Relatively significant incidence of skin exposure due to beta particles when handling 177Lu-labeled therapeutic radiopharmaceuticals, and Increased sensitivity of beta-gamma finger monitors if they are placed on the second point of the index finger.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10304 - Nuclear physics

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů