Axons of retinal ganglion cells on the optic nerve disc following vessel density correction at different IOP values

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F23%3A00366052" target="_blank" >RIV/68407700:21460/23:00366052 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.3892/etm.2023.11960" target="_blank" >https://doi.org/10.3892/etm.2023.11960</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3892/etm.2023.11960" target="_blank" >10.3892/etm.2023.11960</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Axons of retinal ganglion cells on the optic nerve disc following vessel density correction at different IOP values

Popis výsledku v původním jazyce

The present study aimed to determine how the vascular density (VD) in each segment peripapillary influ- ences the retinal nerve fiber layer (RNFL) and to eliminate its contribution to RNFL in pathological intraocular pressure (IOP). In a cohort of 69 subjects (mean age, 45±6 years old) with untreated ocular hypertension (122 eyes in total) enrolled in this study, Ocular Response Analyser IOP was measured during routine outpatient care. Its value was >21 (range, 21-36) mmHg in all eyes. Furthermore, peripapillary VD and RNFL were measured using optical coherence tomography in the following eight segments: Inferior temporal (segment 1); temporal inferior (segment 2); temporal superior (segment 3); superior temporal (segment 4); superior nasal (segment 5); nasal superior (segment 6); nasal inferior (segment 7); and inferior nasal (segment 8). The visual field examination was performed with the fast threshold glaucoma program using the Medmont M 700. The overall defect was evaluated. Person's correlation coefficient was used to assess the correlation between VD and IOP. The largest changes were observed in peripapillary segments 1, 4, 5, 6, 7 and 8. The second part of the work was to eliminate the contribution of VD to RNFL. The partial correlation coefficient r was used to adjust RNFL from VD to assess the dependence between the selected parameters. The largest changes in RNFL were in segments 5 and 8 after they had been `cleaned’ of peripapillary VD. In conclusion, the present study revealed that the largest changes in RNFL after VD adjustment were observed for the incipient hypertensive glaucoma in segments 5 and 8.

Název v anglickém jazyce

Axons of retinal ganglion cells on the optic nerve disc following vessel density correction at different IOP values

Popis výsledku anglicky

The present study aimed to determine how the vascular density (VD) in each segment peripapillary influ- ences the retinal nerve fiber layer (RNFL) and to eliminate its contribution to RNFL in pathological intraocular pressure (IOP). In a cohort of 69 subjects (mean age, 45±6 years old) with untreated ocular hypertension (122 eyes in total) enrolled in this study, Ocular Response Analyser IOP was measured during routine outpatient care. Its value was >21 (range, 21-36) mmHg in all eyes. Furthermore, peripapillary VD and RNFL were measured using optical coherence tomography in the following eight segments: Inferior temporal (segment 1); temporal inferior (segment 2); temporal superior (segment 3); superior temporal (segment 4); superior nasal (segment 5); nasal superior (segment 6); nasal inferior (segment 7); and inferior nasal (segment 8). The visual field examination was performed with the fast threshold glaucoma program using the Medmont M 700. The overall defect was evaluated. Person's correlation coefficient was used to assess the correlation between VD and IOP. The largest changes were observed in peripapillary segments 1, 4, 5, 6, 7 and 8. The second part of the work was to eliminate the contribution of VD to RNFL. The partial correlation coefficient r was used to adjust RNFL from VD to assess the dependence between the selected parameters. The largest changes in RNFL were in segments 5 and 8 after they had been `cleaned’ of peripapillary VD. In conclusion, the present study revealed that the largest changes in RNFL after VD adjustment were observed for the incipient hypertensive glaucoma in segments 5 and 8.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30207 - Ophthalmology

Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

EXPERIMENTAL AND THERAPEUTIC MEDICINE

ISSN

1792-0981

e-ISSN

1792-1015

Svazek periodika

25

Číslo periodika v rámci svazku

2023

Stát vydavatele periodika

GR - Řecká republika

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

000989998000001

EID výsledku v databázi Scopus

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