Randomised control trial of oxygen assist module in preterm infants on high-flow nasal cannula support

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F24%3A00368805" target="_blank" >RIV/68407700:21460/24:00368805 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1136/archdischild-2023-325661" target="_blank" >https://doi.org/10.1136/archdischild-2023-325661</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1136/archdischild-2023-325661" target="_blank" >10.1136/archdischild-2023-325661</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Randomised control trial of oxygen assist module in preterm infants on high-flow nasal cannula support

Popis výsledku v původním jazyce

Objective: To evaluate the efficacy of automatic oxygen control (A-FiO(2)) in reducing the extremes of oxygen saturations (SpO(2)98%) in preterm infants on high-flow nasal cannula (HFNC) respiratory support using Vapotherm Precision Flow.Design: A parallel-arm randomised controlled trial.Setting: A level-III neonatal intensive care unit.Patients: Preterm infants born <33 (23+0 to 32+6) weeks receiving HFNC as respiratory support.Interventions: A-FiO(2) versus manual (M-FiO(2)) oxygen control during the full course of HFNC support.Outcomes:The primary outcome of this study is percentage of time spent in extreme oxygen saturations (98%) in preterm infants when receiving HFNC as respiratory support. Secondary outcomes were time with SpO(2) between 90% and 95% plus time >95% without supplemental oxygen.Results: 60 infants were randomised equally to either A-FiO(2) or M-FiO(2) arm. Their baseline characteristics were comparable. They spent a median of 5.3 (IQR: 2.0-8.4) and 6.5 (IQR: 2.9-13.7) days in the study, A-FiO(2) and M-FiO(2), respectively. The percentage of time spent in SpO(2)<80% (median of 0.4% (0.1%-0.8%) vs 1.6% (0.6%-2.6%), p=0.002) and >98% (median 0.2% (0.1%-0.9%) vs 1.9% (0.7%-4%), p<0.001) were significantly lower in A-FiO(2) compared with M-FiO(2). The difference in median percentage of time in target range between the two arms was 26% (81% (74%-93%) in A-FiO(2) vs 55% (48%-72%) in M-FiO(2)).Conclusion: A-FiO(2) was associated with statistically significant reduction in the percentage of time spent in extremes of saturation when compared with M-FiO(2) in preterm infants receiving HFNC.

Název v anglickém jazyce

Randomised control trial of oxygen assist module in preterm infants on high-flow nasal cannula support

Popis výsledku anglicky

Objective: To evaluate the efficacy of automatic oxygen control (A-FiO(2)) in reducing the extremes of oxygen saturations (SpO(2)98%) in preterm infants on high-flow nasal cannula (HFNC) respiratory support using Vapotherm Precision Flow.Design: A parallel-arm randomised controlled trial.Setting: A level-III neonatal intensive care unit.Patients: Preterm infants born <33 (23+0 to 32+6) weeks receiving HFNC as respiratory support.Interventions: A-FiO(2) versus manual (M-FiO(2)) oxygen control during the full course of HFNC support.Outcomes:The primary outcome of this study is percentage of time spent in extreme oxygen saturations (98%) in preterm infants when receiving HFNC as respiratory support. Secondary outcomes were time with SpO(2) between 90% and 95% plus time >95% without supplemental oxygen.Results: 60 infants were randomised equally to either A-FiO(2) or M-FiO(2) arm. Their baseline characteristics were comparable. They spent a median of 5.3 (IQR: 2.0-8.4) and 6.5 (IQR: 2.9-13.7) days in the study, A-FiO(2) and M-FiO(2), respectively. The percentage of time spent in SpO(2)<80% (median of 0.4% (0.1%-0.8%) vs 1.6% (0.6%-2.6%), p=0.002) and >98% (median 0.2% (0.1%-0.9%) vs 1.9% (0.7%-4%), p<0.001) were significantly lower in A-FiO(2) compared with M-FiO(2). The difference in median percentage of time in target range between the two arms was 26% (81% (74%-93%) in A-FiO(2) vs 55% (48%-72%) in M-FiO(2)).Conclusion: A-FiO(2) was associated with statistically significant reduction in the percentage of time spent in extremes of saturation when compared with M-FiO(2) in preterm infants receiving HFNC.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20601 - Medical engineering

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Archives of disease in childhood. Fetal and neonatal edition

ISSN

1359-2998

e-ISSN

1468-2052

Svazek periodika

109

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

65-69

Kód UT WoS článku

001033880600001

EID výsledku v databázi Scopus

2-s2.0-85166434849