Impact of opioid addition on procedural conditions during colonoscopy: a randomized trial comparing propofol-based sedation protocols

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F25%3A00384097" target="_blank" >RIV/68407700:21460/25:00384097 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.5946/ce.2024.347" target="_blank" >https://doi.org/10.5946/ce.2024.347</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5946/ce.2024.347" target="_blank" >10.5946/ce.2024.347</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Impact of opioid addition on procedural conditions during colonoscopy: a randomized trial comparing propofol-based sedation protocols

Popis výsledku v původním jazyce

Background/Aims Propofol is the most effective sedative for colonoscopy; however, opioids do have several adverse effects that need to be discussed. The objective of this study was to compare the ease of colonoscopy during propofol-based sedation with and without fentanyl, while closely monitoring ventilatory data and the safety of the procedure. Methods This prospective single-center trial randomized 50 patients who underwent minor colonoscopies. The propofol group received sedation exclusively via propofol, whereas the propofol+fentanyl group was premedicated with 1 µg/kg fentanyl. Patients were monitored using a bioimpedance ventilatory monitor, and both the patients and endoscopists were questioned regarding their level of satisfaction. Results The endoscopists reported a higher level of ease with the colonoscopy procedure (mean on a 5-point scale, 1.2 vs. 1.72; p=0.028) and the overall patient satisfaction score was higher (1.15 vs. 1.28, p=0.026) in the propofol+fentanyl group. No significant differences were observed in the ventilatory parameters between the groups. No major adverse events were reported in any of the groups. Conclusions The inclusion of fentanyl leads to enhanced levels of satisfaction for both the endoscopist and the patient, without any impact on ventilation and safety. The use of bioimpedance monitoring of ventilation during colonoscopy is a suitable approach that may enhance the safety of procedural sedation.

Název v anglickém jazyce

Impact of opioid addition on procedural conditions during colonoscopy: a randomized trial comparing propofol-based sedation protocols

Popis výsledku anglicky

Background/Aims Propofol is the most effective sedative for colonoscopy; however, opioids do have several adverse effects that need to be discussed. The objective of this study was to compare the ease of colonoscopy during propofol-based sedation with and without fentanyl, while closely monitoring ventilatory data and the safety of the procedure. Methods This prospective single-center trial randomized 50 patients who underwent minor colonoscopies. The propofol group received sedation exclusively via propofol, whereas the propofol+fentanyl group was premedicated with 1 µg/kg fentanyl. Patients were monitored using a bioimpedance ventilatory monitor, and both the patients and endoscopists were questioned regarding their level of satisfaction. Results The endoscopists reported a higher level of ease with the colonoscopy procedure (mean on a 5-point scale, 1.2 vs. 1.72; p=0.028) and the overall patient satisfaction score was higher (1.15 vs. 1.28, p=0.026) in the propofol+fentanyl group. No significant differences were observed in the ventilatory parameters between the groups. No major adverse events were reported in any of the groups. Conclusions The inclusion of fentanyl leads to enhanced levels of satisfaction for both the endoscopist and the patient, without any impact on ventilation and safety. The use of bioimpedance monitoring of ventilation during colonoscopy is a suitable approach that may enhance the safety of procedural sedation.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30219 - Gastroenterology and hepatology

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Endoscopy

ISSN

2234-2443

e-ISSN

2234-2443

Svazek periodika

58

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

KR - Korejská republika

Počet stran výsledku

9

Strana od-do

722-730

Kód UT WoS článku

001525067700001

EID výsledku v databázi Scopus

2-s2.0-105020726156