Neuroprotective Citicoline in Primary Open-angle Glaucoma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F25%3A00385815" target="_blank" >RIV/68407700:21460/25:00385815 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.55920/JCRMHS.2025.13.001561" target="_blank" >https://doi.org/10.55920/JCRMHS.2025.13.001561</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.55920/JCRMHS.2025.13.001561" target="_blank" >10.55920/JCRMHS.2025.13.001561</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Neuroprotective Citicoline in Primary Open-angle Glaucoma

Popis výsledku v původním jazyce

Purpose: The aim of this study was to determine whether systemic cicoline administration affects vessel density (VD) and retinal nerve fiber layer (RNFL) in compensated primary open-angle glaucoma (POAG). Material and Methods: The cohort consisted of two groups of patients with early stage POAG. Each group consisted of 10 people (20 eyes), 5 women and 5 men. The first group was treated with carteolol (carteol LP 2% eye drops) and the second with latanoprost (xalatan 0.005% eye drops). The duration of treatment was at least one year, Citicoline (NEUROTidine 50 mg/ml) was then added to both groups and taken for 4 months as an oral dose of 2x5 ml. Before the inclusion of citicoline and after the 4 months of oral administration, we evaluated vessel density in the peripapillary region (all vessels: PP-VDa, small vessels: PP-VDs) and in the whole image region (all vessels: WI-VDa, small vessels: WI-VDs), retinal nerve fiber layer (RNFL), intraocular pressure (IOP) and overall defect (OD) of the visual field. Results: There was no a priori difference between groups for these parameters (PP-VDa, PP-VDs, WI-VDa, WI-VDs, RNFL and OD) before citicoline deployment (P>0.05). IOP was statistically significantly different at the beginning of the study (carteolol 17,1 mmHg, latanoprost 14,89 mmHg). However, this difference was not of clinical significance as the values were normal. Following the 4 months of combined treatment that included citicoline, we found no statistically significant differences for either group in terms of before, and after citicoline, except for IOP, which increased by 2.7 mmHg in the eyes treated with latanoprost (P=0.05). Eyes treated with carteolol had a reduction in IOP. This change was not statistically significant. Conclusion: No significant changes in VD or RNFL were found following citicoline addition to latanoprost or carteolol.

Název v anglickém jazyce

Neuroprotective Citicoline in Primary Open-angle Glaucoma

Popis výsledku anglicky

Purpose: The aim of this study was to determine whether systemic cicoline administration affects vessel density (VD) and retinal nerve fiber layer (RNFL) in compensated primary open-angle glaucoma (POAG). Material and Methods: The cohort consisted of two groups of patients with early stage POAG. Each group consisted of 10 people (20 eyes), 5 women and 5 men. The first group was treated with carteolol (carteol LP 2% eye drops) and the second with latanoprost (xalatan 0.005% eye drops). The duration of treatment was at least one year, Citicoline (NEUROTidine 50 mg/ml) was then added to both groups and taken for 4 months as an oral dose of 2x5 ml. Before the inclusion of citicoline and after the 4 months of oral administration, we evaluated vessel density in the peripapillary region (all vessels: PP-VDa, small vessels: PP-VDs) and in the whole image region (all vessels: WI-VDa, small vessels: WI-VDs), retinal nerve fiber layer (RNFL), intraocular pressure (IOP) and overall defect (OD) of the visual field. Results: There was no a priori difference between groups for these parameters (PP-VDa, PP-VDs, WI-VDa, WI-VDs, RNFL and OD) before citicoline deployment (P>0.05). IOP was statistically significantly different at the beginning of the study (carteolol 17,1 mmHg, latanoprost 14,89 mmHg). However, this difference was not of clinical significance as the values were normal. Following the 4 months of combined treatment that included citicoline, we found no statistically significant differences for either group in terms of before, and after citicoline, except for IOP, which increased by 2.7 mmHg in the eyes treated with latanoprost (P=0.05). Eyes treated with carteolol had a reduction in IOP. This change was not statistically significant. Conclusion: No significant changes in VD or RNFL were found following citicoline addition to latanoprost or carteolol.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

—

OECD FORD obor

30207 - Ophthalmology

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Clinical Case Reports, Medical Images and Health Sciences

ISSN

2832-1286

e-ISSN

2832-1286

Svazek periodika

13

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

1-7

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—