Atlas-Guided Tractography for Segmentation of Striatal Subregions in Early Parkinson’s Disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F25%3A00386730" target="_blank" >RIV/68407700:21460/25:00386730 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1051/bioconf/202519502004" target="_blank" >https://doi.org/10.1051/bioconf/202519502004</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1051/bioconf/202519502004" target="_blank" >10.1051/bioconf/202519502004</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Atlas-Guided Tractography for Segmentation of Striatal Subregions in Early Parkinson’s Disease

Popis výsledku v původním jazyce

Parkinson’s disease (PD) and isolated REM sleep behaviour disorder (iRBD) are neurodegenerative conditions associated with alterations in the striatum, a subcortical structure essential for motor and cognitive functions. In this study, we apply diffusion tensor imaging (DTI) and probabilistic tractography to segment the striatum into two functionally distinct compartments: striosomes and matrix. A total of 152 subjects were included: 64 PD patients, 47 iRBD patients, and 41 healthy controls. Preprocessing, tractography, and segmentation were performed using the FSL toolbox; voxel-based morphometry (VBM) was used for group comparisons. Probabilistic group atlases were constructed in MNI space and compared with each other and with the standard MNI_152 atlas using RMSE and statistical testing. Results show significant differences in the matrix region, particularly in the right striatum of iRBD subjects compared to both PD and control groups. Our findings suggest that connectivity-based striatal segmentation may reflect early structural changes in neurodegeneration and could support future biomarker development for PD and related disorders. This tractography-based approach offers a promising tool for the personalized analysis of subcortical brain structures in clinical neuroimaging.

Název v anglickém jazyce

Atlas-Guided Tractography for Segmentation of Striatal Subregions in Early Parkinson’s Disease

Popis výsledku anglicky

Parkinson’s disease (PD) and isolated REM sleep behaviour disorder (iRBD) are neurodegenerative conditions associated with alterations in the striatum, a subcortical structure essential for motor and cognitive functions. In this study, we apply diffusion tensor imaging (DTI) and probabilistic tractography to segment the striatum into two functionally distinct compartments: striosomes and matrix. A total of 152 subjects were included: 64 PD patients, 47 iRBD patients, and 41 healthy controls. Preprocessing, tractography, and segmentation were performed using the FSL toolbox; voxel-based morphometry (VBM) was used for group comparisons. Probabilistic group atlases were constructed in MNI space and compared with each other and with the standard MNI_152 atlas using RMSE and statistical testing. Results show significant differences in the matrix region, particularly in the right striatum of iRBD subjects compared to both PD and control groups. Our findings suggest that connectivity-based striatal segmentation may reflect early structural changes in neurodegeneration and could support future biomarker development for PD and related disorders. This tractography-based approach offers a promising tool for the personalized analysis of subcortical brain structures in clinical neuroimaging.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

Projekt

<a href="/cs/project/LX22NPO5107" target="_blank" >LX22NPO5107: Národní ústav pro neurologický výzkum</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

BIO web of conferences

ISBN

—

ISSN

2273-1709

e-ISSN

2117-4458

Počet stran výsledku

10

Strana od-do

1-10

Název nakladatele

EDP Sciences

Místo vydání

Les Ulis

Místo konání akce

Prague

Datum konání akce

12. 9. 2025

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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