Significant Improvement of Biocompatibility of Polypropylene Mesh for Incisional Hernia Repair by Using Poly-?-Caprolactone Nanofibers Functionalized with Thrombocyte-Rich Solution

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21720%2F15%3A00232099" target="_blank" >RIV/68407700:21720/15:00232099 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21460/15:00232099

Výsledek na webu

<a href="http://dx.doi.org/10.2147/IJN.S77816" target="_blank" >http://dx.doi.org/10.2147/IJN.S77816</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2147/IJN.S77816" target="_blank" >10.2147/IJN.S77816</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Significant Improvement of Biocompatibility of Polypropylene Mesh for Incisional Hernia Repair by Using Poly-?-Caprolactone Nanofibers Functionalized with Thrombocyte-Rich Solution

Popis výsledku v původním jazyce

Incisional hernia is the most common postoperative complication, affecting up to 20% of patients after abdominal surgery. Insertion of a synthetic surgical mesh has become the standard of care in ventral hernia repair. However, the implementation of a mesh does not reduce the risk of recurrence and the onset of hernia recurrence is only delayed by 2-3 years. Nowadays, more than 100 surgical meshes are available on the market, with polypropylene the most widely used for ventral hernia repair. Nonetheless, the ideal mesh does not exist yet; it still needs to be developed. Polycaprolactone nanofibers appear to be a suitable material for different kinds of cells, including fibroblasts, chondrocytes, and mesenchymal stem cells. The aim of the study reportedhere was to develop a functionalized scaffold for ventral hernia regeneration. We prepared a novel composite scaffold based on a polypropylene surgical mesh functionalized with poly-?-caprolactone (PCL) nanofibers and adhered thrombocyte

Název v anglickém jazyce

Significant Improvement of Biocompatibility of Polypropylene Mesh for Incisional Hernia Repair by Using Poly-?-Caprolactone Nanofibers Functionalized with Thrombocyte-Rich Solution

Popis výsledku anglicky

Incisional hernia is the most common postoperative complication, affecting up to 20% of patients after abdominal surgery. Insertion of a synthetic surgical mesh has become the standard of care in ventral hernia repair. However, the implementation of a mesh does not reduce the risk of recurrence and the onset of hernia recurrence is only delayed by 2-3 years. Nowadays, more than 100 surgical meshes are available on the market, with polypropylene the most widely used for ventral hernia repair. Nonetheless, the ideal mesh does not exist yet; it still needs to be developed. Polycaprolactone nanofibers appear to be a suitable material for different kinds of cells, including fibroblasts, chondrocytes, and mesenchymal stem cells. The aim of the study reportedhere was to develop a functionalized scaffold for ventral hernia regeneration. We prepared a novel composite scaffold based on a polypropylene surgical mesh functionalized with poly-?-caprolactone (PCL) nanofibers and adhered thrombocyte

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EI - Biotechnologie a bionika

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Nanomedicine

ISSN

1178-2013

e-ISSN

—

Svazek periodika

10

Číslo periodika v rámci svazku

April

Stát vydavatele periodika

NZ - Nový Zéland

Počet stran výsledku

12

Strana od-do

2635-2646

Kód UT WoS článku

000352013200002

EID výsledku v databázi Scopus

2-s2.0-84928138287