Emulsion Centrifugal Spinning for Production of 3D Drug Releasing Nanofibers with Core/Shell Structure
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21720%2F17%3A00310206" target="_blank" >RIV/68407700:21720/17:00310206 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1039/c6ra26606a" target="_blank" >http://dx.doi.org/10.1039/c6ra26606a</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c6ra26606a" target="_blank" >10.1039/c6ra26606a</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Emulsion Centrifugal Spinning for Production of 3D Drug Releasing Nanofibers with Core/Shell Structure
Popis výsledku v původním jazyce
Herein we describe the core/shell centrifugal spinning process to deliver susceptible bioactive molecules. The fibres are produced from water-in-oil (W/O) emulsion, where poly-ε-caprolactone (PCL) dissolved in chloroform serves as the continuous phase and Pluronic F-68 (PF-68) dissolved in ethanol serves as the droplet phase. The successful core/shell fibre formation and discontinuous morphology of the core was identified by confocal microscopy. Encapsulation of a model enzyme resulted in protection of enzymatic activity and release during the first 7 days. The feasibility for tissue engineering applications was demonstrated by the incorporation of platelet lyophilisates as a source of growth factors. The cultivation of 3T3 fibroblasts and MG63 osteoblasts resulted in improved metabolic activity and fostered proliferation. Results of the study indicate that the proposed scaffold combines the 3D structure of scaffolds produced by centrifugal spinning with the drug delivery of growth factors.
Název v anglickém jazyce
Emulsion Centrifugal Spinning for Production of 3D Drug Releasing Nanofibers with Core/Shell Structure
Popis výsledku anglicky
Herein we describe the core/shell centrifugal spinning process to deliver susceptible bioactive molecules. The fibres are produced from water-in-oil (W/O) emulsion, where poly-ε-caprolactone (PCL) dissolved in chloroform serves as the continuous phase and Pluronic F-68 (PF-68) dissolved in ethanol serves as the droplet phase. The successful core/shell fibre formation and discontinuous morphology of the core was identified by confocal microscopy. Encapsulation of a model enzyme resulted in protection of enzymatic activity and release during the first 7 days. The feasibility for tissue engineering applications was demonstrated by the incorporation of platelet lyophilisates as a source of growth factors. The cultivation of 3T3 fibroblasts and MG63 osteoblasts resulted in improved metabolic activity and fostered proliferation. Results of the study indicate that the proposed scaffold combines the 3D structure of scaffolds produced by centrifugal spinning with the drug delivery of growth factors.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
21001 - Nano-materials (production and properties)
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2017
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
RSC Advances
ISSN
2046-2069
e-ISSN
2046-2069
Svazek periodika
7
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
14
Strana od-do
1215-1228
Kód UT WoS článku
000393744400003
EID výsledku v databázi Scopus
2-s2.0-85009391363