Electrical Stimulation Modulates High Gamma Activity and Human Memory Performance.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21730%2F18%3A00319218" target="_blank" >RIV/68407700:21730/18:00319218 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.eneuro.org/content/early/2018/01/24/ENEURO.0369-17.2018" target="_blank" >http://www.eneuro.org/content/early/2018/01/24/ENEURO.0369-17.2018</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1523/ENEURO.0369-17.2018" target="_blank" >10.1523/ENEURO.0369-17.2018</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Electrical Stimulation Modulates High Gamma Activity and Human Memory Performance.

Popis výsledku v původním jazyce

Direct electrical stimulation of the brain has emerged as a powerful treatment for multiple neurological diseases, and as a potential technique to enhance human cognition. Despite its application in a range of brain disorders, it remains unclear how stimulation of discrete brain areas affects memory performance and the underlying electrophysiological activities. Here, we investigated the effect of direct electrical stimulation in four brain regions known to support declarative memory: hippocampus, parahippocampal neocortex, prefrontal cortex and lateral temporal cortex. Intracranial EEG recordings with stimulation were collected from 22 patients during performance of verbal memory tasks. We found that high gamma (62-118 Hz) activity induced by word presentation was modulated by electrical stimulation. This modulatory effect was greatest for trials with `poor’ memory encoding. The high gamma modulation correlated with the behavioral effect of stimulation in a given brain region – it was negative, i.e. the induced high gamma activity was decreased, in the regions where stimulation decreased memory performance, and positive in the lateral temporal cortex where memory enhancement was observed. Our results suggest that the effect of electrical stimulation on high gamma activity induced by word presentation may be a useful biomarker for mapping memory networks and guiding therapeutic brain stimulation.

Název v anglickém jazyce

Electrical Stimulation Modulates High Gamma Activity and Human Memory Performance.

Popis výsledku anglicky

Direct electrical stimulation of the brain has emerged as a powerful treatment for multiple neurological diseases, and as a potential technique to enhance human cognition. Despite its application in a range of brain disorders, it remains unclear how stimulation of discrete brain areas affects memory performance and the underlying electrophysiological activities. Here, we investigated the effect of direct electrical stimulation in four brain regions known to support declarative memory: hippocampus, parahippocampal neocortex, prefrontal cortex and lateral temporal cortex. Intracranial EEG recordings with stimulation were collected from 22 patients during performance of verbal memory tasks. We found that high gamma (62-118 Hz) activity induced by word presentation was modulated by electrical stimulation. This modulatory effect was greatest for trials with `poor’ memory encoding. The high gamma modulation correlated with the behavioral effect of stimulation in a given brain region – it was negative, i.e. the induced high gamma activity was decreased, in the regions where stimulation decreased memory performance, and positive in the lateral temporal cortex where memory enhancement was observed. Our results suggest that the effect of electrical stimulation on high gamma activity induced by word presentation may be a useful biomarker for mapping memory networks and guiding therapeutic brain stimulation.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

20601 - Medical engineering

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

eNeuro

ISSN

2373-2822

e-ISSN

2373-2822

Svazek periodika

5

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

—

Kód UT WoS článku

000429409900047

EID výsledku v databázi Scopus

2-s2.0-85042085339