From Cross-sectional To Longitudinal: Insights Into Cholinergic White Matter Changes In Alzheimer’s Disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21730%2F24%3A00381702" target="_blank" >RIV/68407700:21730/24:00381702 - isvavai.cz</a>

Výsledek na webu

<a href="https://cslide.ctimeetingtech.com/adpd24/attendee/confcal/show/session/70" target="_blank" >https://cslide.ctimeetingtech.com/adpd24/attendee/confcal/show/session/70</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

From Cross-sectional To Longitudinal: Insights Into Cholinergic White Matter Changes In Alzheimer’s Disease

Popis výsledku v původním jazyce

Aims Accumulating evidence underscores the vulnerability of the cholinergic nucleus basalis of Meynert and itswhite matter projections in Alzheimer's disease (AD) dementia, mild cognitive impairment (MCI), and notably,even in subjective cognitive decline (SCD). Expanding on these observations, we aim to present results from across-sectional study detailing these microstructural alterations and introduce a currently developinglongitudinal pipeline specifically tailored to monitor cholinergic white matter pathway changes across the ADcontinuum. Methods We evaluated 402 participants (52 AD, 66 MCI, 172 SCD, and 112 healthy controls) from the DELCODE studyover a period of up to 4 years post-baseline, with annual visits. We employed an advanced diffusion imagingtechnique, integrating probabilistic fiber-tracking with prior anatomical data, to create a comprehensive modelof the cholinergic white matter pathways. We assessed the integrity of these pathways both in the completeparticipant group and within a subset stratified by CSF amyloid-beta levels, contrasting these across differentstages of the AD continuum. Furthermore, we will be introducing a longitudinal analysis approach,implementing mixed-effect models on the tract level, to our research pipeline. Results Data assessments revealed a progressive decline in the integrity of cholinergic white matter pathwaysthroughout the AD continuum. Already evident in SCD individuals, early changes predominantly involved theposterior cholinergic white matter. As the disease progressed to MCI and then AD dementia stages, alterationsextended to the anterior frontal white matter. Conclusions Our research suggests that alterations in cholinergic white matter pathways manifest already in individuals withSCD. These results indicate that the integrity of cholinergic pathways holds potential as a reliable biomarker forearly neurodegeneration within the AD continuum.

Název v anglickém jazyce

From Cross-sectional To Longitudinal: Insights Into Cholinergic White Matter Changes In Alzheimer’s Disease

Popis výsledku anglicky

Aims Accumulating evidence underscores the vulnerability of the cholinergic nucleus basalis of Meynert and itswhite matter projections in Alzheimer's disease (AD) dementia, mild cognitive impairment (MCI), and notably,even in subjective cognitive decline (SCD). Expanding on these observations, we aim to present results from across-sectional study detailing these microstructural alterations and introduce a currently developinglongitudinal pipeline specifically tailored to monitor cholinergic white matter pathway changes across the ADcontinuum. Methods We evaluated 402 participants (52 AD, 66 MCI, 172 SCD, and 112 healthy controls) from the DELCODE studyover a period of up to 4 years post-baseline, with annual visits. We employed an advanced diffusion imagingtechnique, integrating probabilistic fiber-tracking with prior anatomical data, to create a comprehensive modelof the cholinergic white matter pathways. We assessed the integrity of these pathways both in the completeparticipant group and within a subset stratified by CSF amyloid-beta levels, contrasting these across differentstages of the AD continuum. Furthermore, we will be introducing a longitudinal analysis approach,implementing mixed-effect models on the tract level, to our research pipeline. Results Data assessments revealed a progressive decline in the integrity of cholinergic white matter pathwaysthroughout the AD continuum. Already evident in SCD individuals, early changes predominantly involved theposterior cholinergic white matter. As the disease progressed to MCI and then AD dementia stages, alterationsextended to the anterior frontal white matter. Conclusions Our research suggests that alterations in cholinergic white matter pathways manifest already in individuals withSCD. These results indicate that the integrity of cholinergic pathways holds potential as a reliable biomarker forearly neurodegeneration within the AD continuum.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20601 - Medical engineering

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů