Regional associations between cerebrovascular disease and cholinergic white matter pathways in the Lewy body continuum

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21730%2F25%3A00385966" target="_blank" >RIV/68407700:21730/25:00385966 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1038/s41531-025-01118-5" target="_blank" >https://doi.org/10.1038/s41531-025-01118-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41531-025-01118-5" target="_blank" >10.1038/s41531-025-01118-5</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Regional associations between cerebrovascular disease and cholinergic white matter pathways in the Lewy body continuum

Popis výsledku v původním jazyce

Cerebrovascular disease is common in patients on the Lewy body (LB) continuum (dementia with Lewy bodies (DLB) and prodromal-DLB). White matter signal abnormality (WMSA) volume is higher in patients with LB than controls, both globally and in cholinergic white matter. However, it remains unknown if the higher WMSA in cholinergic white matter reflects selective cholinergic vulnerability or results from higher global WMSA. We modelled cingulate and external capsule cholinergic white matter pathways using MRI and segmented WMSA overlapping cholinergic pathways and per brain lobe. We found that patients on the LB-continuum (n = 33) had higher volume and proportion of WMSA in the cholinergic white matter compared to controls (n = 36), independent of global WMSA. Cholinergic WMSA was associated with neurodegeneration in the basal forebrain, decreased integrity of cingulate and external capsule pathways and attention and memory performance. These findings may suggest a selective vulnerability of cholinergic pathways in patients with LB.

Název v anglickém jazyce

Regional associations between cerebrovascular disease and cholinergic white matter pathways in the Lewy body continuum

Popis výsledku anglicky

Cerebrovascular disease is common in patients on the Lewy body (LB) continuum (dementia with Lewy bodies (DLB) and prodromal-DLB). White matter signal abnormality (WMSA) volume is higher in patients with LB than controls, both globally and in cholinergic white matter. However, it remains unknown if the higher WMSA in cholinergic white matter reflects selective cholinergic vulnerability or results from higher global WMSA. We modelled cingulate and external capsule cholinergic white matter pathways using MRI and segmented WMSA overlapping cholinergic pathways and per brain lobe. We found that patients on the LB-continuum (n = 33) had higher volume and proportion of WMSA in the cholinergic white matter compared to controls (n = 36), independent of global WMSA. Cholinergic WMSA was associated with neurodegeneration in the basal forebrain, decreased integrity of cingulate and external capsule pathways and attention and memory performance. These findings may suggest a selective vulnerability of cholinergic pathways in patients with LB.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20601 - Medical engineering

Projekt

<a href="/cs/project/GM25-18359M" target="_blank" >GM25-18359M: Kvantitativní strukturální a funkční zobrazování lidského cholinergního systému s aplikacemi v kognitivní vědě a neurodegenerativních poruchách</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

npj Parkinsons Disease

ISSN

2373-8057

e-ISSN

—

Svazek periodika

11

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

1-10

Kód UT WoS článku

001554531500001

EID výsledku v databázi Scopus

2-s2.0-105013865143