Optimization of biodegradable polymeric submicroparticles preparation

Kód výsledku v IS VaVaI

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Nalezeny alternativní kódy

RIV/70883521:28610/11:43866347

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Optimization of biodegradable polymeric submicroparticles preparation

Popis výsledku v původním jazyce

The influence of various surfactants and their combinations on the particle diameter and particles size distribution during their preparation from biodegradable poly(lactide acid) by the method of emulsification and solvent evaporation at reduced pressure was investigated. The attention was focused on the possibility to control the size of resultant particles by hydrophilic-lipophilic balance parameter (HLB), which is a characteristic of nonionic surfactants. First, nonionic surfactants were combined toobtain various HLB values of the system and then combinations with the biodegradable surface active polymer Gelatin A were assayed. Gelatin A proved to be a suitable emulsion stabilizer in the process of PLA submicroparticles preparation and it was found that to achieve PLA submicroparticles with the lowest diameter and narrow distribution HLB of the system has to be set up under about 16. For combinations of gelatin A and another nonionic surfactant the reduction of the aggregate HLB v

Název v anglickém jazyce

Optimization of biodegradable polymeric submicroparticles preparation

Popis výsledku anglicky

The influence of various surfactants and their combinations on the particle diameter and particles size distribution during their preparation from biodegradable poly(lactide acid) by the method of emulsification and solvent evaporation at reduced pressure was investigated. The attention was focused on the possibility to control the size of resultant particles by hydrophilic-lipophilic balance parameter (HLB), which is a characteristic of nonionic surfactants. First, nonionic surfactants were combined toobtain various HLB values of the system and then combinations with the biodegradable surface active polymer Gelatin A were assayed. Gelatin A proved to be a suitable emulsion stabilizer in the process of PLA submicroparticles preparation and it was found that to achieve PLA submicroparticles with the lowest diameter and narrow distribution HLB of the system has to be set up under about 16. For combinations of gelatin A and another nonionic surfactant the reduction of the aggregate HLB v

Druh

D - Stať ve sborníku

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Recent Researches in Geography, Geology, Energy, Environment and Biomedicine - Proc. of the 4th WSEAS Int. Conf. on EMESEG'11, 2nd Int. Conf. on WORLD-GEO'11, 5th Int. Conf. on EDEB'11

ISBN

978-1-61804-022-0

ISSN

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e-ISSN

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Počet stran výsledku

6

Strana od-do

294-299

Název nakladatele

WSEAS Press (GR)

Místo vydání

Rhodes

Místo konání akce

Corfu Island

Datum konání akce

14. 7. 2011

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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