A study of 2-substituted 3,1-benzoxazin-4-ones

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F12%3A43869044" target="_blank" >RIV/70883521:28110/12:43869044 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

A study of 2-substituted 3,1-benzoxazin-4-ones

Popis výsledku v původním jazyce

This paper describes our work concerning the preparation of novel benzoxazinones substituted with indole moiety or acyl in position 2. Their preparation is achieved by cyclodehydration of the appropriate N-acylanthranilic acids by means of acetic anhydride or thionyl chloride, which is consistent with the standard procedure. In addition, a new route to starting N-acylanthranilic acids has been established. Firstly, N-(?-ketoacyl)anthranilic acids were readily obtained from 4-hydroxyquinolin-2-ones by two-step oxidation including peracetic acid hydroxylation into the corresponding 3-hydroxyquinoline-2,4-diones and subsequent oxidative ring opening with periodic acid or sodium periodate. In the cases of the preparation of the mentioned indole derivatives, the appropriate transformations of ?-ketoacyl chain were carried out by known chemistry. As a part of our continued interest in the reactivity of various heterocyclic systems, we have studied reactions of title compounds with some nucle

Název v anglickém jazyce

A study of 2-substituted 3,1-benzoxazin-4-ones

Popis výsledku anglicky

This paper describes our work concerning the preparation of novel benzoxazinones substituted with indole moiety or acyl in position 2. Their preparation is achieved by cyclodehydration of the appropriate N-acylanthranilic acids by means of acetic anhydride or thionyl chloride, which is consistent with the standard procedure. In addition, a new route to starting N-acylanthranilic acids has been established. Firstly, N-(?-ketoacyl)anthranilic acids were readily obtained from 4-hydroxyquinolin-2-ones by two-step oxidation including peracetic acid hydroxylation into the corresponding 3-hydroxyquinoline-2,4-diones and subsequent oxidative ring opening with periodic acid or sodium periodate. In the cases of the preparation of the mentioned indole derivatives, the appropriate transformations of ?-ketoacyl chain were carried out by known chemistry. As a part of our continued interest in the reactivity of various heterocyclic systems, we have studied reactions of title compounds with some nucle

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemické listy

ISSN

0009-2770

e-ISSN

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Svazek periodika

2012

Číslo periodika v rámci svazku

106

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

1

Strana od-do

1342

Kód UT WoS článku

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EID výsledku v databázi Scopus

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