SYNTHESIS OF NOVEL AMPHUPHILIC HYALURONAN CONTAINING pi(.) (.) (.)pi CONJUGATED MOIETIES AS CARRIERS FOR DRUG DELIVERY

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

SYNTHESIS OF NOVEL AMPHUPHILIC HYALURONAN CONTAINING pi(.) (.) (.)pi CONJUGATED MOIETIES AS CARRIERS FOR DRUG DELIVERY

Popis výsledku v původním jazyce

Hyaluronan (HA) was chemically modified using various co-phenyl/ heteroaromatic alkanoic acids differing in the length of alkyl chains. HA was modified on hydroxyl moieties to keep carboxylic acid moieties unchanged. Prepared products were characterized using nuclear magnetic resonance (H-1, DOSY, HSQC), infrared spectroscopy and SEC-MALS. To determine whether the derivatives are suitable for drug delivery applications, the cell toxicity and critical aggregation concentrations were determined. The micelles of selected derivatives were loaded with aromatic hydrophobic drugs and the actual drug loading contents of these various micelles were compared.

Název v anglickém jazyce

SYNTHESIS OF NOVEL AMPHUPHILIC HYALURONAN CONTAINING pi(.) (.) (.)pi CONJUGATED MOIETIES AS CARRIERS FOR DRUG DELIVERY

Popis výsledku anglicky

Hyaluronan (HA) was chemically modified using various co-phenyl/ heteroaromatic alkanoic acids differing in the length of alkyl chains. HA was modified on hydroxyl moieties to keep carboxylic acid moieties unchanged. Prepared products were characterized using nuclear magnetic resonance (H-1, DOSY, HSQC), infrared spectroscopy and SEC-MALS. To determine whether the derivatives are suitable for drug delivery applications, the cell toxicity and critical aggregation concentrations were determined. The micelles of selected derivatives were loaded with aromatic hydrophobic drugs and the actual drug loading contents of these various micelles were compared.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

10404 - Polymer science

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

PROCEEDINGS OF THE 12TH INTERNATIONAL CONFERENCE ON POLYSACCHARIDES-GLYCOSCIENCE, 2016

ISBN

978-80-86238-59-3

ISSN

2336-6796

e-ISSN

neuvedeno

Počet stran výsledku

4

Strana od-do

63-66

Název nakladatele

Czech Chemical Society

Místo vydání

Prague

Místo konání akce

Praha

Datum konání akce

19. 10. 2016

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000388249900015