The cosmetic and dermatological potential of keratin hydrolysate

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F17%3A63517066" target="_blank" >RIV/70883521:28110/17:63517066 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1111/jocd.12319" target="_blank" >http://dx.doi.org/10.1111/jocd.12319</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jocd.12319" target="_blank" >10.1111/jocd.12319</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The cosmetic and dermatological potential of keratin hydrolysate

Popis výsledku v původním jazyce

Background: Although keratin hydrolysates have become established as standard components in hair and nail cosmetics, studies on the moisturizing effects of keratin hydrolysates do not appear among contemporary literature. Objectives: To test if adding keratin hydrolysate into an ointment base increases hydration of the skin and improves skin barrier function, or diminishes trans-epidermal water loss. Methods: Formulations were prepared containing 2%, 4%, and 6% keratin hydrolysates (based on weight of the ointment base). The moisturizing properties of keratin hydrolysates were tested by measuring skin hydration, trans-epidermal water loss and skin pH; measurements were carried out at intervals of 1, 2, 3, 4, 24, and 48 h. Testing was conducted on 10 women. Results: As regards hydration, adding 2% keratin hydrolysate to the ointment base is optimal, as an increase of 14%-23% occurs in hydration of the stratum corneum. For trans-epidermal water loss, adding 4% KH to the ointment base is preferential, as this triggers a 26%-46% decrease in trans-epidermal water loss. Conclusions: Keratin hydrolysate acts as a humectant (it binds water from lower layers of the epidermis to the stratum corneum) as well as an occlusive (it reduces trans-epidermal water loss). The highly favorable properties of keratin hydrolysates are attributed to the wide distribution of keratin hydrolysates molecular weights; low-molecular weight fractions easily penetrate the SC, while high-molecular weight fractions form a protective film on the epidermis. Adding keratin hydrolysates to the ointment base did not cause phase separation even after 6 mo storage.

Název v anglickém jazyce

The cosmetic and dermatological potential of keratin hydrolysate

Popis výsledku anglicky

Background: Although keratin hydrolysates have become established as standard components in hair and nail cosmetics, studies on the moisturizing effects of keratin hydrolysates do not appear among contemporary literature. Objectives: To test if adding keratin hydrolysate into an ointment base increases hydration of the skin and improves skin barrier function, or diminishes trans-epidermal water loss. Methods: Formulations were prepared containing 2%, 4%, and 6% keratin hydrolysates (based on weight of the ointment base). The moisturizing properties of keratin hydrolysates were tested by measuring skin hydration, trans-epidermal water loss and skin pH; measurements were carried out at intervals of 1, 2, 3, 4, 24, and 48 h. Testing was conducted on 10 women. Results: As regards hydration, adding 2% keratin hydrolysate to the ointment base is optimal, as an increase of 14%-23% occurs in hydration of the stratum corneum. For trans-epidermal water loss, adding 4% KH to the ointment base is preferential, as this triggers a 26%-46% decrease in trans-epidermal water loss. Conclusions: Keratin hydrolysate acts as a humectant (it binds water from lower layers of the epidermis to the stratum corneum) as well as an occlusive (it reduces trans-epidermal water loss). The highly favorable properties of keratin hydrolysates are attributed to the wide distribution of keratin hydrolysates molecular weights; low-molecular weight fractions easily penetrate the SC, while high-molecular weight fractions form a protective film on the epidermis. Adding keratin hydrolysates to the ointment base did not cause phase separation even after 6 mo storage.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30216 - Dermatology and venereal diseases

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Cosmetic Dermatology

ISSN

1473-2130

e-ISSN

—

Svazek periodika

16

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

"e21"-"e27"

Kód UT WoS článku

000416913500004

EID výsledku v databázi Scopus

2-s2.0-85012877459