Antibacterial Activity of Immobilized Glucosamine/ Chondroitin Sulfate on Polylactic Acid Films

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F19%3A63522500" target="_blank" >RIV/70883521:28110/19:63522500 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/70883521:28610/19:63522500

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Antibacterial Activity of Immobilized Glucosamine/ Chondroitin Sulfate on Polylactic Acid Films

Popis výsledku v původním jazyce

Polylactic acid (PLA) is one of the most produced polymeric material derived from renewable sources due to its exceptional chemical and mechanical properties. These properties such as biodegradability and biocompatibility make them attractive for medical and biological applications. Conversely, the major drawback of PLA in biomedical applications is vulnerability to bacterial contaminations. This study focuses on the immobilization of a polysaccharide onto PLA surface by multistep approach to provide an antibacterial feature. In this approach, after poly (acrylic acid) (PAA) brushes attach non-covalently to the PLA surface via plasma post-irradiation grafting technique, immobilization of GlcN and ChS to the PAA brushes were carried out. To understand the changes in surface properties, such as chemical composition, surface topography and hydrophilicity, untreated and treated PLA films were analyzed using various characterization techniques such as contact angle, scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). Antibacterial activity of the samples was tested against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The results clearly indicate that plasma-treated films immobilized with GlcN/ChS demonstrated outstanding activity against the selected microorganisms.

Název v anglickém jazyce

Antibacterial Activity of Immobilized Glucosamine/ Chondroitin Sulfate on Polylactic Acid Films

Popis výsledku anglicky

Polylactic acid (PLA) is one of the most produced polymeric material derived from renewable sources due to its exceptional chemical and mechanical properties. These properties such as biodegradability and biocompatibility make them attractive for medical and biological applications. Conversely, the major drawback of PLA in biomedical applications is vulnerability to bacterial contaminations. This study focuses on the immobilization of a polysaccharide onto PLA surface by multistep approach to provide an antibacterial feature. In this approach, after poly (acrylic acid) (PAA) brushes attach non-covalently to the PLA surface via plasma post-irradiation grafting technique, immobilization of GlcN and ChS to the PAA brushes were carried out. To understand the changes in surface properties, such as chemical composition, surface topography and hydrophilicity, untreated and treated PLA films were analyzed using various characterization techniques such as contact angle, scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). Antibacterial activity of the samples was tested against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The results clearly indicate that plasma-treated films immobilized with GlcN/ChS demonstrated outstanding activity against the selected microorganisms.

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů