Utilization of Dialdehyde Cellulose as Crosslinker for Poly(vinyl alcohol)

Kód výsledku v IS VaVaI

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RIV/70883521:28610/19:63524203

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Utilization of Dialdehyde Cellulose as Crosslinker for Poly(vinyl alcohol)

Popis výsledku v původním jazyce

Crosslinking agents based on modified biopolymers are particularly favorable in biomedical sector as alternatives to toxic synthetic low-molecular weight crosslinkers (i.e. glutaraldehyde). Periodate oxidation of cellulose produces dialdehyde cellulose (DAC) which can be solubilized1 and used as crosslinker for poly(vinyl alcohol) (PVA).2 Solubilization is recognized as key step influencing molecular weight of DAC.3 Furthermore, due to high reactivity of aldehyde groups (–CHO), DAC decays in time.1 Nevertheless, DAC can be stabilized for several weeks when kept at low pH.3 The reactive DAC species form hemiacetal bonds with hydroxyl groups of PVA in presence of acid catalyst. In contrast to low molecular crosslinker-based hydrogels, resulting network presumably possesses very different crosslink topology and lower toxicity arising from the DAC macromolecular character.2,4 PVA/DAC materials may found application in pharmaceutics as materials for wound dressing or drug release. The scope of this study was to utilize a broad range of concentrations of solubilized DAC and glutaraldehyde (GA) in PVA hydrogel formation and evaluate their efficiency.

Název v anglickém jazyce

Utilization of Dialdehyde Cellulose as Crosslinker for Poly(vinyl alcohol)

Popis výsledku anglicky

Crosslinking agents based on modified biopolymers are particularly favorable in biomedical sector as alternatives to toxic synthetic low-molecular weight crosslinkers (i.e. glutaraldehyde). Periodate oxidation of cellulose produces dialdehyde cellulose (DAC) which can be solubilized1 and used as crosslinker for poly(vinyl alcohol) (PVA).2 Solubilization is recognized as key step influencing molecular weight of DAC.3 Furthermore, due to high reactivity of aldehyde groups (–CHO), DAC decays in time.1 Nevertheless, DAC can be stabilized for several weeks when kept at low pH.3 The reactive DAC species form hemiacetal bonds with hydroxyl groups of PVA in presence of acid catalyst. In contrast to low molecular crosslinker-based hydrogels, resulting network presumably possesses very different crosslink topology and lower toxicity arising from the DAC macromolecular character.2,4 PVA/DAC materials may found application in pharmaceutics as materials for wound dressing or drug release. The scope of this study was to utilize a broad range of concentrations of solubilized DAC and glutaraldehyde (GA) in PVA hydrogel formation and evaluate their efficiency.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20901 - Industrial biotechnology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů