Improved tack characterization of transdermal therapeutic systems (TTS)

Kód výsledku v IS VaVaI

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RIV/70883521:28610/19:63524308

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Improved tack characterization of transdermal therapeutic systems (TTS)

Popis výsledku v původním jazyce

Transdermal patches are designed for drug delivery trough human skin for several disease treatments. They consist of Pressure Sensitive Adhesives (PSA) and a protective Backing Layer (BL). Excellent short-term and long-term adhesion of the PSA to skin during application time is essential for patient&apos;s compliance. A challenge within TTS development is to choose suitable PSA mixtures and appropriate BL to meet all requirements. Currently short time adhesion of TTS is measured by the Probe Tack according to ASTM D2979. In the Probe Tack experiment the maximum force due to initial adhesion is determined with a stainless steel stamp Ø = 5 mm after a contact time of 1 s. However, the &quot;real&quot; adhesion behavior of the TTS due to effects of different adhesive mixtures and BL is characterized by a force-time-curve. It allows for to evaluate the maximum force as well as the cohesive energy and the maximal detach rate. Therefore, the Haake MARS III rheometer in normal stress mode was used to measure force-time curves of these patches. This method is named &quot;Rheo-Tack&quot;. In this study, the short-term adhesion behavior of five types of silicone based adhesives (55% - 60 % resin) on two different BL (19 μm PET; 52 μm PET/EVA) is determined using both the Probe Tack Tester and Rheo-Tack. First results show increasing cohesive energies with decreasing resin contents and increasing layer thicknesses of the PSAs. Furthermore, the maximal detach rate given by the minimal slope of the force-time-curve after reaching the maximum force increases with decreasing resin contents, and the maximum force values correspond to the Probe Tack values. The Rheo-Tack method provides considerably more information about the patch behavior for optimization purposes of TTS without loosing the standardized Probe-Tack values.

Název v anglickém jazyce

Improved tack characterization of transdermal therapeutic systems (TTS)

Popis výsledku anglicky

Transdermal patches are designed for drug delivery trough human skin for several disease treatments. They consist of Pressure Sensitive Adhesives (PSA) and a protective Backing Layer (BL). Excellent short-term and long-term adhesion of the PSA to skin during application time is essential for patient&apos;s compliance. A challenge within TTS development is to choose suitable PSA mixtures and appropriate BL to meet all requirements. Currently short time adhesion of TTS is measured by the Probe Tack according to ASTM D2979. In the Probe Tack experiment the maximum force due to initial adhesion is determined with a stainless steel stamp Ø = 5 mm after a contact time of 1 s. However, the &quot;real&quot; adhesion behavior of the TTS due to effects of different adhesive mixtures and BL is characterized by a force-time-curve. It allows for to evaluate the maximum force as well as the cohesive energy and the maximal detach rate. Therefore, the Haake MARS III rheometer in normal stress mode was used to measure force-time curves of these patches. This method is named &quot;Rheo-Tack&quot;. In this study, the short-term adhesion behavior of five types of silicone based adhesives (55% - 60 % resin) on two different BL (19 μm PET; 52 μm PET/EVA) is determined using both the Probe Tack Tester and Rheo-Tack. First results show increasing cohesive energies with decreasing resin contents and increasing layer thicknesses of the PSAs. Furthermore, the maximal detach rate given by the minimal slope of the force-time-curve after reaching the maximum force increases with decreasing resin contents, and the maximum force values correspond to the Probe Tack values. The Rheo-Tack method provides considerably more information about the patch behavior for optimization purposes of TTS without loosing the standardized Probe-Tack values.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20501 - Materials engineering

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů