Large Amplitude Oscillatory Shear Tests of Pressure Sensitive Adhesives Designed for Transdermal Therapeutic Systems

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F20%3A63527076" target="_blank" >RIV/70883521:28110/20:63527076 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/70883521:28610/20:63527076

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Large Amplitude Oscillatory Shear Tests of Pressure Sensitive Adhesives Designed for Transdermal Therapeutic Systems

Popis výsledku v původním jazyce

Transdermal Therapeutic Systems (TTS) based on pressure sensitive adhesives (PSA) allow for application of pharmaceutical substances via diffusion through the skin. Rheological performance of PSA is largely investigated within small amplitude oscillatory shear (typically up to 1 %), although the skin motions exceed strains beyond 40 %. In this paper, amine compatible (AC) and non-amine compatible (NAC) silicone based PSA compounds differing in the resin content were subjected to strain amplitude sweeps in a twin drive rheometer. Carreau-Yasuda-like fitting of storage and loss moduli curves intercept the substantial effect of resin content on both compounds; up to four-times higher moduli of AC compounds were determined in SAOS, and their higher molecular mass combined with enhanced interactions contributed to an earlier transition to nonlinear viscoelastic region. In the nonlinear range, elastic and viscous properties are affected by strains in a different manner with the trend favorable for the PSA application as TTS. Importantly, the nonlinear coefficient Q(γ_0 ) was found to be inappropriate to quantify nonlinear behavior for PSA. Instead, the third relative higher harmonic from Fourier transformation I_(3/1) as well as intra-cycle strain stiffening and shear thickening ratios provide information relevant for an optimization of PSA subjected to large deformations.

Název v anglickém jazyce

Large Amplitude Oscillatory Shear Tests of Pressure Sensitive Adhesives Designed for Transdermal Therapeutic Systems

Popis výsledku anglicky

Transdermal Therapeutic Systems (TTS) based on pressure sensitive adhesives (PSA) allow for application of pharmaceutical substances via diffusion through the skin. Rheological performance of PSA is largely investigated within small amplitude oscillatory shear (typically up to 1 %), although the skin motions exceed strains beyond 40 %. In this paper, amine compatible (AC) and non-amine compatible (NAC) silicone based PSA compounds differing in the resin content were subjected to strain amplitude sweeps in a twin drive rheometer. Carreau-Yasuda-like fitting of storage and loss moduli curves intercept the substantial effect of resin content on both compounds; up to four-times higher moduli of AC compounds were determined in SAOS, and their higher molecular mass combined with enhanced interactions contributed to an earlier transition to nonlinear viscoelastic region. In the nonlinear range, elastic and viscous properties are affected by strains in a different manner with the trend favorable for the PSA application as TTS. Importantly, the nonlinear coefficient Q(γ_0 ) was found to be inappropriate to quantify nonlinear behavior for PSA. Instead, the third relative higher harmonic from Fourier transformation I_(3/1) as well as intra-cycle strain stiffening and shear thickening ratios provide information relevant for an optimization of PSA subjected to large deformations.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10404 - Polymer science

Projekt

<a href="/cs/project/LO1504" target="_blank" >LO1504: Centrum polymerních systémů plus</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů