Long-term antimicrobial effect of polylactide-based composites suitable for biomedical use

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F22%3A63555581" target="_blank" >RIV/70883521:28110/22:63555581 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61988987:17310/22:A2302GPJ RIV/61989100:27730/22:10250348 RIV/61989100:27640/22:10250348

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0142941822002811?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0142941822002811?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.polymertesting.2022.107760" target="_blank" >10.1016/j.polymertesting.2022.107760</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Long-term antimicrobial effect of polylactide-based composites suitable for biomedical use

Popis výsledku v původním jazyce

This work deals with the preparation and characterization of antimicrobial polymeric composite materials based on polylactide, which is currently widely investigated to produce temporary implants. Polylactide was blended with antimicrobial fillers: silver, hexadecylpyridinium or hexadecyltrimethylammonium bromides anchored on vermiculite or graphene oxide matrices in an amount of 1% wt. The prepared samples were characterized by conventional methods, further they were exposed to degradation tests in physiological saline conditions and characterized for their antimicrobial properties using common pathogen microorganisms. It has been proven that the prepared polylactide composites change their antimicrobial effects after being in physiological saline of pH 7 and 9 for 0–6 months. The weight of the composites changed by about 10%, and antimicrobial properties were growing over time. The effectiveness of the composites was confirmed for 6 months at minimum. Therefore, they are suitable for the preparation of temporary stents, catheters or implants suitable for fracture fixation.

Název v anglickém jazyce

Long-term antimicrobial effect of polylactide-based composites suitable for biomedical use

Popis výsledku anglicky

This work deals with the preparation and characterization of antimicrobial polymeric composite materials based on polylactide, which is currently widely investigated to produce temporary implants. Polylactide was blended with antimicrobial fillers: silver, hexadecylpyridinium or hexadecyltrimethylammonium bromides anchored on vermiculite or graphene oxide matrices in an amount of 1% wt. The prepared samples were characterized by conventional methods, further they were exposed to degradation tests in physiological saline conditions and characterized for their antimicrobial properties using common pathogen microorganisms. It has been proven that the prepared polylactide composites change their antimicrobial effects after being in physiological saline of pH 7 and 9 for 0–6 months. The weight of the composites changed by about 10%, and antimicrobial properties were growing over time. The effectiveness of the composites was confirmed for 6 months at minimum. Therefore, they are suitable for the preparation of temporary stents, catheters or implants suitable for fracture fixation.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

20505 - Composites (including laminates, reinforced plastics, cermets, combined natural and synthetic fibre fabrics; filled composites)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Polymer Testing

ISSN

0142-9418

e-ISSN

1873-2348

Svazek periodika

116

Číslo periodika v rámci svazku

Neuveden

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

nestrankovano

Kód UT WoS článku

000861129800004

EID výsledku v databázi Scopus

2-s2.0-85137723316