Design and fabrication of electrospun PLA-based silica-modified composite nanofibers with antibacterial properties for perspective wound treatment
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F23%3A63569603" target="_blank" >RIV/70883521:28110/23:63569603 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/70883521:28610/23:63569603
Výsledek na webu
<a href="https://www.mdpi.com/2073-4360/15/17/3500" target="_blank" >https://www.mdpi.com/2073-4360/15/17/3500</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/polym15173500" target="_blank" >10.3390/polym15173500</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Design and fabrication of electrospun PLA-based silica-modified composite nanofibers with antibacterial properties for perspective wound treatment
Popis výsledku v původním jazyce
The aim of this study was to develop a novel amikacin (AMI) delivery system with prolonged release based on composite electrospun nanofibers of PLA supplemented with AMI-loaded Si nanoparticles of different morphology. The resultant materials were characterized in terms of their physical properties (scanning electron microscopy, Brunauer-Emmett-Teller analysis, thermogravimetric analysis, water contact angle). High-Performance Liquid Chromatography was used to determine the AMI content in the liquid fractions obtained from the release study. The results show that nanofibers of fumed silica exhibited an aggregated, highly porous structure, whereas nanofibers of mesoporous silica had a spherical morphology. Both silica nanoparticles had a significant effect on the hydrophilic properties of PLA nanofiber surfaces. The liquid fractions were investigated to gauge the encapsulation efficiency (EE) and loading efficiency (LE) of AMI, demonstrating 66% EE and 52% LE for nanofibers of fumed silica compared to nanofibers of mesoporous silica nanoparticles (52% EE and 12.7% LE). The antibacterial activity of the AMI-loaded nanofibers was determined by the Kirby-Bauer Method. These results demonstrated that the PLA-based silica nanofibers effectively enhanced the antibacterial properties against the Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae.
Název v anglickém jazyce
Design and fabrication of electrospun PLA-based silica-modified composite nanofibers with antibacterial properties for perspective wound treatment
Popis výsledku anglicky
The aim of this study was to develop a novel amikacin (AMI) delivery system with prolonged release based on composite electrospun nanofibers of PLA supplemented with AMI-loaded Si nanoparticles of different morphology. The resultant materials were characterized in terms of their physical properties (scanning electron microscopy, Brunauer-Emmett-Teller analysis, thermogravimetric analysis, water contact angle). High-Performance Liquid Chromatography was used to determine the AMI content in the liquid fractions obtained from the release study. The results show that nanofibers of fumed silica exhibited an aggregated, highly porous structure, whereas nanofibers of mesoporous silica had a spherical morphology. Both silica nanoparticles had a significant effect on the hydrophilic properties of PLA nanofiber surfaces. The liquid fractions were investigated to gauge the encapsulation efficiency (EE) and loading efficiency (LE) of AMI, demonstrating 66% EE and 52% LE for nanofibers of fumed silica compared to nanofibers of mesoporous silica nanoparticles (52% EE and 12.7% LE). The antibacterial activity of the AMI-loaded nanofibers was determined by the Kirby-Bauer Method. These results demonstrated that the PLA-based silica nanofibers effectively enhanced the antibacterial properties against the Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10404 - Polymer science
Návaznosti výsledku
Projekt
—
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2023
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Polymers
ISSN
2073-4360
e-ISSN
—
Svazek periodika
15
Číslo periodika v rámci svazku
17
Stát vydavatele periodika
CH - Švýcarská konfederace
Počet stran výsledku
16
Strana od-do
—
Kód UT WoS článku
001061156500001
EID výsledku v databázi Scopus
2-s2.0-85170370757