Hyaluronan-based magneto-responsive hydrogel for biomedical applications
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F23%3A63571138" target="_blank" >RIV/70883521:28110/23:63571138 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/70883521:28610/23:63571138
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Hyaluronan-based magneto-responsive hydrogel for biomedical applications
Popis výsledku v původním jazyce
A magneto-responsive hydrogel composed of hyaluronan-based (HA) matrix cross-linked via Schiff base formation, magnetic multicore particles (MCPs), and Al2O3 nanoparticles was elaborated. MCPs ensure the hydrogel heating (0.3 °C/minute) under exposure to an alternating magnetic field (AMF) approved for medicine. Rheological measurements confirmed shear-thinning behavior and fast recovery after high shear stress. Hydrogel was proven to be cytocompatible, with improved long-term stability at cell cultivation conditions. Viscoelastic properties of the hydrogel allowed extrusion-based 3D bioprinting with BALB/3T3 mouse fibroblasts forming self-supported, multi-layered, uniformly porous structure with homogeneous cell distribution and high cell viability. High heating efficiency, softness, biocompatibility, and 3D printability of magnetic HA hydrogel make it a multifunctional material suitable for AMF induced heating in biomedical applications such as magnetic hyperthermia, wireless thermal brain stimulation, thermally triggered drug delivery as well as for precise scaffold engineering and bioprinting.
Název v anglickém jazyce
Hyaluronan-based magneto-responsive hydrogel for biomedical applications
Popis výsledku anglicky
A magneto-responsive hydrogel composed of hyaluronan-based (HA) matrix cross-linked via Schiff base formation, magnetic multicore particles (MCPs), and Al2O3 nanoparticles was elaborated. MCPs ensure the hydrogel heating (0.3 °C/minute) under exposure to an alternating magnetic field (AMF) approved for medicine. Rheological measurements confirmed shear-thinning behavior and fast recovery after high shear stress. Hydrogel was proven to be cytocompatible, with improved long-term stability at cell cultivation conditions. Viscoelastic properties of the hydrogel allowed extrusion-based 3D bioprinting with BALB/3T3 mouse fibroblasts forming self-supported, multi-layered, uniformly porous structure with homogeneous cell distribution and high cell viability. High heating efficiency, softness, biocompatibility, and 3D printability of magnetic HA hydrogel make it a multifunctional material suitable for AMF induced heating in biomedical applications such as magnetic hyperthermia, wireless thermal brain stimulation, thermally triggered drug delivery as well as for precise scaffold engineering and bioprinting.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
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OECD FORD obor
30404 - Biomaterials (as related to medical implants, devices, sensors)
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2023
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů