Heating efficiency study of amino acid coated iron oxide nanoparticles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F24%3A63589120" target="_blank" >RIV/70883521:28110/24:63589120 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/70883521:28610/24:63589120

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Heating efficiency study of amino acid coated iron oxide nanoparticles

Popis výsledku v původním jazyce

Magnetic nanoparticles possess a variety of interesting physical and chemical properties, which offer opportunities for their use in different applications. Iron oxide magnetic nanoparticles (IONPs) are widely studied for their potential use in biological or medical application. Among them, magnetic fluid hyperthermia seems to be a perspective and advantageous way for cancer treatment. Magnetic fluid hyperthermia is using the ability of IONPs to generate heat under the applied alternating magnetic field. The efficiency of the hyperthermic treatment is affected among others by the surface chemistry of nanoparticles and their heating properties. In this study, electrostatically stabilized iron oxide nanoparticles (MNPs) were synthetized and subsequently modified by amino acids cysteine (Cys) and proline (Pro) and by a poly amino acid poly-L-lysine (PLL) to enhance their biocompatibility. The prepared samples were labelled as Cys-MNPs, Pro-MNPs and PLL-MNPs and were characterized in terms of size distribution, zeta potential and magnetic properties. The hydrodynamic diameter determined by Dynamic Light Scattering method was 32, 67, 35 and 46 nm for MNPs, Cys-, Pro- and PLL-MNPs, respectively. All of the studied nanoparticles samples are positively charged with the zeta potential values ranging from 30 mV for unmodified MNPs to 48 mV for PLLMNPs. Then the heating efficiencies of the nanoparticles suspensions in water and agarose gel were measured at 1049 kHz, 7.4 mT and from the heating rates the specific loss power values (SLP) were evaluated. The obtained SLP values are encouraging for further study and potential use in hyperthermia.

Název v anglickém jazyce

Heating efficiency study of amino acid coated iron oxide nanoparticles

Popis výsledku anglicky

Magnetic nanoparticles possess a variety of interesting physical and chemical properties, which offer opportunities for their use in different applications. Iron oxide magnetic nanoparticles (IONPs) are widely studied for their potential use in biological or medical application. Among them, magnetic fluid hyperthermia seems to be a perspective and advantageous way for cancer treatment. Magnetic fluid hyperthermia is using the ability of IONPs to generate heat under the applied alternating magnetic field. The efficiency of the hyperthermic treatment is affected among others by the surface chemistry of nanoparticles and their heating properties. In this study, electrostatically stabilized iron oxide nanoparticles (MNPs) were synthetized and subsequently modified by amino acids cysteine (Cys) and proline (Pro) and by a poly amino acid poly-L-lysine (PLL) to enhance their biocompatibility. The prepared samples were labelled as Cys-MNPs, Pro-MNPs and PLL-MNPs and were characterized in terms of size distribution, zeta potential and magnetic properties. The hydrodynamic diameter determined by Dynamic Light Scattering method was 32, 67, 35 and 46 nm for MNPs, Cys-, Pro- and PLL-MNPs, respectively. All of the studied nanoparticles samples are positively charged with the zeta potential values ranging from 30 mV for unmodified MNPs to 48 mV for PLLMNPs. Then the heating efficiencies of the nanoparticles suspensions in water and agarose gel were measured at 1049 kHz, 7.4 mT and from the heating rates the specific loss power values (SLP) were evaluated. The obtained SLP values are encouraging for further study and potential use in hyperthermia.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

<a href="/cs/project/8X23034" target="_blank" >8X23034: Magnetické nanostruktury schopné samozahřívání pro teranostické aplikace</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů