RheoTack evaluation of detaching behavior of silicone-based pressure sensitive adhesives for transdermal therapeutic systems

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F25%3A63594740" target="_blank" >RIV/70883521:28110/25:63594740 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/70883521:28610/25:63594740

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S026322412500795X?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S026322412500795X?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.measurement.2025.117436" target="_blank" >10.1016/j.measurement.2025.117436</a>

Jazyk výsledku

angličtina

Název v původním jazyce

RheoTack evaluation of detaching behavior of silicone-based pressure sensitive adhesives for transdermal therapeutic systems

Popis výsledku v původním jazyce

This study focuses on applying the RheoTack method to assess the detaching behavior of transdermal therapeutic systems (TTS), which represent skin-applied medications comprising a drug-loaded pressure-sensitive adhesive (PSA) and a flexible backing layer. The RheoTack method provides detailed force-retraction displacement-curves (F-h-curves) that reveal the influence of chemical structure and resin content on PSA deformation and fibril formation. To compare various rod geometries (flat rods with diameters of 5 mm and 8 mm, and a spherically rounded rod with a contact area of 5 mm2), the force-retraction displacement curves were normalized to account for the effective contact areas. The flat and spherical rods led to completely different F-h-curves as well as different failure and tack behaviors. Furthermore, the adhesion formation between the TTS with flexible backing layers and rods during the dwell phase occurs in a different manner compared with rigid plates, particularly for flat rods, where maximum compression stresses occur at the edges and not uniformly over the cross-section. Measurements of F-h-curves were performed with retraction speeds of 0.01, 0.1, and 1 mm/s. The increase in retraction speed increased the stiffness from 250 to 1200 N/m for non-amine-compatible PSA measured with a rod of 8 mm. RheoTack measurements were performed with a dwell time of 1 s, which is consistent with ASTM D2949. However, the TTS was in the adhesion-establishing compression phase for 3 s at 1 mm/s and for 30 s at 0.01 mm/s. Thus, the approach to follow ASTM D2949 has to be reconsidered for testing TTS materials.

Název v anglickém jazyce

RheoTack evaluation of detaching behavior of silicone-based pressure sensitive adhesives for transdermal therapeutic systems

Popis výsledku anglicky

This study focuses on applying the RheoTack method to assess the detaching behavior of transdermal therapeutic systems (TTS), which represent skin-applied medications comprising a drug-loaded pressure-sensitive adhesive (PSA) and a flexible backing layer. The RheoTack method provides detailed force-retraction displacement-curves (F-h-curves) that reveal the influence of chemical structure and resin content on PSA deformation and fibril formation. To compare various rod geometries (flat rods with diameters of 5 mm and 8 mm, and a spherically rounded rod with a contact area of 5 mm2), the force-retraction displacement curves were normalized to account for the effective contact areas. The flat and spherical rods led to completely different F-h-curves as well as different failure and tack behaviors. Furthermore, the adhesion formation between the TTS with flexible backing layers and rods during the dwell phase occurs in a different manner compared with rigid plates, particularly for flat rods, where maximum compression stresses occur at the edges and not uniformly over the cross-section. Measurements of F-h-curves were performed with retraction speeds of 0.01, 0.1, and 1 mm/s. The increase in retraction speed increased the stiffness from 250 to 1200 N/m for non-amine-compatible PSA measured with a rod of 8 mm. RheoTack measurements were performed with a dwell time of 1 s, which is consistent with ASTM D2949. However, the TTS was in the adhesion-establishing compression phase for 3 s at 1 mm/s and for 30 s at 0.01 mm/s. Thus, the approach to follow ASTM D2949 has to be reconsidered for testing TTS materials.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20302 - Applied mechanics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Measurement

ISSN

0263-2241

e-ISSN

—

Svazek periodika

253

Číslo periodika v rámci svazku

Part A

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

nestránkováno

Kód UT WoS článku

001463102300001

EID výsledku v databázi Scopus

2-s2.0-105001736708