Freeze-dried pickering emulsions with curcumin: The role of stabilizers and cryoprotectants

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F25%3A63596998" target="_blank" >RIV/70883521:28110/25:63596998 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/70883521:28610/25:63596998

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acsomega.4c09731" target="_blank" >https://pubs.acs.org/doi/10.1021/acsomega.4c09731</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsomega.4c09731" target="_blank" >10.1021/acsomega.4c09731</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Freeze-dried pickering emulsions with curcumin: The role of stabilizers and cryoprotectants

Popis výsledku v původním jazyce

This study investigated freeze-dried Pickering emulsions stabilized by a combination of cellulose nanocrystals (CNCs) and sodium caseinate (CAS), with encapsulated curcumin. Our approach focused on the order of CNC/CAS addition and its influence on emulsion properties, along with the effect of three different cryoprotectants (sucrose, d-mannitol, and d-glucose) on the preservation of emulsion droplets. In the study, controlled release of curcumin from freeze-dried emulsions was achieved, attributed to the composition of the stabilizing layer and the cryoprotectant used. The emulsions were partially able to withstand freeze-drying and could be redispersed to samples with droplets bigger than those observed before freeze-drying. The best-preserved droplets came from emulsions stabilized first by CNC particles and then by CAS addition and protected with d-glucose. Transdermal penetration studies revealed that curcumin was mainly present on the skin’s surface and at the stratum corneum, with limited penetration into deeper skin layers. Nevertheless, the samples showed outstanding antioxidant activity and no cytotoxicity effects, demonstrating their promising potential to positively influence the healing of the skin.

Název v anglickém jazyce

Freeze-dried pickering emulsions with curcumin: The role of stabilizers and cryoprotectants

Popis výsledku anglicky

This study investigated freeze-dried Pickering emulsions stabilized by a combination of cellulose nanocrystals (CNCs) and sodium caseinate (CAS), with encapsulated curcumin. Our approach focused on the order of CNC/CAS addition and its influence on emulsion properties, along with the effect of three different cryoprotectants (sucrose, d-mannitol, and d-glucose) on the preservation of emulsion droplets. In the study, controlled release of curcumin from freeze-dried emulsions was achieved, attributed to the composition of the stabilizing layer and the cryoprotectant used. The emulsions were partially able to withstand freeze-drying and could be redispersed to samples with droplets bigger than those observed before freeze-drying. The best-preserved droplets came from emulsions stabilized first by CNC particles and then by CAS addition and protected with d-glucose. Transdermal penetration studies revealed that curcumin was mainly present on the skin’s surface and at the stratum corneum, with limited penetration into deeper skin layers. Nevertheless, the samples showed outstanding antioxidant activity and no cytotoxicity effects, demonstrating their promising potential to positively influence the healing of the skin.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

<a href="/cs/project/GA23-07425S" target="_blank" >GA23-07425S: Anisotropní a elektricky vodivé biomateriály</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ACS Omega

ISSN

2470-1343

e-ISSN

—

Svazek periodika

10

Číslo periodika v rámci svazku

26

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

27722-27734

Kód UT WoS článku

001518549100001

EID výsledku v databázi Scopus

2-s2.0-105009721105