Powder injection molded ceramic scaffolds: The role of pores size and surface functionalization on the cytocompatibility

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28140%2F22%3A63556861" target="_blank" >RIV/70883521:28140/22:63556861 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/70883521:28610/22:63556861 RIV/70883521:28110/22:63556861

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0264127522008966?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0264127522008966?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.matdes.2022.111274" target="_blank" >10.1016/j.matdes.2022.111274</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Powder injection molded ceramic scaffolds: The role of pores size and surface functionalization on the cytocompatibility

Popis výsledku v původním jazyce

The alumina-based scaffolds prepared by powder injection molding can be preferentially used for preparation of bone grafts. Here, the final architecture of alumina scaffolds was efficiently controlled by powder space holder size and volume ratio. The alumina is not intrinsically cell-instructive material and thus the coating with electrically-conducting polyaniline or polyaniline/biopolymer films prepared in a colloidal dispersion mode was used to provide this advanced property. The component of the extracellular matrix, sodium hyaluronate, or natural biopolymers (sodium alginate or chitosan) were employed, and, subsequently, the cytocompatibility of the native and functionalized alumina scaffolds were determined. Both the absence of cytotoxicity and the cytocompatibility that were revealed demonstrate the application potential of these composites. The scaffolds with pore size greater than 250 µm were more cytocompatibility than those with pores size between 125 and 250 µm. The cytocompatibility was confirmed under in vivo-mimicking dynamic cultivation conditions which further improve the cell distribution and growth.

Název v anglickém jazyce

Powder injection molded ceramic scaffolds: The role of pores size and surface functionalization on the cytocompatibility

Popis výsledku anglicky

The alumina-based scaffolds prepared by powder injection molding can be preferentially used for preparation of bone grafts. Here, the final architecture of alumina scaffolds was efficiently controlled by powder space holder size and volume ratio. The alumina is not intrinsically cell-instructive material and thus the coating with electrically-conducting polyaniline or polyaniline/biopolymer films prepared in a colloidal dispersion mode was used to provide this advanced property. The component of the extracellular matrix, sodium hyaluronate, or natural biopolymers (sodium alginate or chitosan) were employed, and, subsequently, the cytocompatibility of the native and functionalized alumina scaffolds were determined. Both the absence of cytotoxicity and the cytocompatibility that were revealed demonstrate the application potential of these composites. The scaffolds with pore size greater than 250 µm were more cytocompatibility than those with pores size between 125 and 250 µm. The cytocompatibility was confirmed under in vivo-mimicking dynamic cultivation conditions which further improve the cell distribution and growth.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20504 - Ceramics

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Materials and Design

ISSN

0261-3069

e-ISSN

1873-4197

Svazek periodika

224

Číslo periodika v rámci svazku

Neuveden

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

nestrankovano

Kód UT WoS článku

000882331300001

EID výsledku v databázi Scopus

2-s2.0-85140885696