In Vitro Models for Testing the Effect of Mediator on Heating in Electro-Hypertermia

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

In Vitro Models for Testing the Effect of Mediator on Heating in Electro-Hypertermia

Popis výsledku v původním jazyce

Background: The ability of magnetic particles to be heated up by AC magnetic field has outlined a new effective method for tumour?s treatment ? magnetic hyperthermia. Recently there?ve been attempts to use the energy of electric field for the same purpose. The electro hyperthermia method works due to the significant difference in conductivity of malignant and healthy tissue which makes the method selective. Although the penetration depth of electric field is smaller than in the case of magnetic field, its absorption efficiency is higher. In order to increase the efficiency further we proposed to use electrically lossy magnetic fluid as a mediator in electro-hyperthermia. Methods: To test the effect of mediator on the heating of malignant cells, the hepatocellular carcinoma cell line (Hep G2; ATCC) and human immortalized non-tumorigenic keratinocyte cell line (HaCaT; CLS were used) were used. As the mediator, maghemite-based ferrofluid with special morphology giving rise to high dielect

Název v anglickém jazyce

In Vitro Models for Testing the Effect of Mediator on Heating in Electro-Hypertermia

Popis výsledku anglicky

Background: The ability of magnetic particles to be heated up by AC magnetic field has outlined a new effective method for tumour?s treatment ? magnetic hyperthermia. Recently there?ve been attempts to use the energy of electric field for the same purpose. The electro hyperthermia method works due to the significant difference in conductivity of malignant and healthy tissue which makes the method selective. Although the penetration depth of electric field is smaller than in the case of magnetic field, its absorption efficiency is higher. In order to increase the efficiency further we proposed to use electrically lossy magnetic fluid as a mediator in electro-hyperthermia. Methods: To test the effect of mediator on the heating of malignant cells, the hepatocellular carcinoma cell line (Hep G2; ATCC) and human immortalized non-tumorigenic keratinocyte cell line (HaCaT; CLS were used) were used. As the mediator, maghemite-based ferrofluid with special morphology giving rise to high dielect

Druh

O - Ostatní výsledky

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů