Bacteriostatic activity of fluoroquinolone coatings on polyethylene films

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F15%3A43873014" target="_blank" >RIV/70883521:28610/15:43873014 - isvavai.cz</a>

Výsledek na webu

<a href="http://link.springer.com/article/10.1007/s00289-015-1388-2/fulltext.html" target="_blank" >http://link.springer.com/article/10.1007/s00289-015-1388-2/fulltext.html</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00289-015-1388-2" target="_blank" >10.1007/s00289-015-1388-2</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Bacteriostatic activity of fluoroquinolone coatings on polyethylene films

Popis výsledku v původním jazyce

Low-density polyethylene films were surface modified through a three-step procedure to impart antibacterial property. Plasma treatment was followed by allylamine grafting to generate active functionalities on the surface. Three potent antibiotics including norfloxacin, ciprofloxacin and ofloxacin were then separately coated onto the surfaces. Each step of surface modification was well characterized in terms of chemical composition and bioactivity. It was found that the chemical structure of the antibiotic was highly determining in extent of antibiotic immobilization as well as in final biological performance of the modified substrates. An excellent activity against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacterial growth was observed for norfloxacin-coated substrate which corresponded to the highest amount of the antibiotic immobilized. However, almost no activity was seen for ofloxacin-coated surface. This was attributed to the ease of the antibiotic

Název v anglickém jazyce

Bacteriostatic activity of fluoroquinolone coatings on polyethylene films

Popis výsledku anglicky

Low-density polyethylene films were surface modified through a three-step procedure to impart antibacterial property. Plasma treatment was followed by allylamine grafting to generate active functionalities on the surface. Three potent antibiotics including norfloxacin, ciprofloxacin and ofloxacin were then separately coated onto the surfaces. Each step of surface modification was well characterized in terms of chemical composition and bioactivity. It was found that the chemical structure of the antibiotic was highly determining in extent of antibiotic immobilization as well as in final biological performance of the modified substrates. An excellent activity against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacterial growth was observed for norfloxacin-coated substrate which corresponded to the highest amount of the antibiotic immobilized. However, almost no activity was seen for ofloxacin-coated surface. This was attributed to the ease of the antibiotic

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

JK - Koroze a povrchové úpravy materiálu

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Polymer Bulletin

ISSN

0170-0839

e-ISSN

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Svazek periodika

72

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

2049-2058

Kód UT WoS článku

000358413000014

EID výsledku v databázi Scopus

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