Nisin immobilization into polyester based microspheres

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F16%3A43874560" target="_blank" >RIV/70883521:28610/16:43874560 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/70883521:28610/16:43874603

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Nisin immobilization into polyester based microspheres

Popis výsledku v původním jazyce

This work is focused on preparation of nisin containing multicomponent microspheres comprising a core based on unmodified polyvinyl alcohol (PVA) crosslinked with glutaric acid (GA) at various degrees. The shell of the microspheres consists of biodegradable polylactic acid (PLA). Encapsulation of nisin in PLA/PVA microspheres was conducted by emulsification solvent evaporation technique. Morphology of the microspheres was studied by using electron microscopy. The efficiency of encapsulation and release kinetics of nisin were evaluated by HPLC. The results revealed that the presence of nisin in the microspheres has no significant effect on their morphology. On the contrary, it was found that the crosslinking degree of PVA increases the average size of the prepared microspheres and also broadens their size distribution. Encapsulation efficiency showed higher values for the non-crosslinked (> 90%) that for the crosslinked PVA systems (> 50%).

Název v anglickém jazyce

Nisin immobilization into polyester based microspheres

Popis výsledku anglicky

This work is focused on preparation of nisin containing multicomponent microspheres comprising a core based on unmodified polyvinyl alcohol (PVA) crosslinked with glutaric acid (GA) at various degrees. The shell of the microspheres consists of biodegradable polylactic acid (PLA). Encapsulation of nisin in PLA/PVA microspheres was conducted by emulsification solvent evaporation technique. Morphology of the microspheres was studied by using electron microscopy. The efficiency of encapsulation and release kinetics of nisin were evaluated by HPLC. The results revealed that the presence of nisin in the microspheres has no significant effect on their morphology. On the contrary, it was found that the crosslinking degree of PVA increases the average size of the prepared microspheres and also broadens their size distribution. Encapsulation efficiency showed higher values for the non-crosslinked (> 90%) that for the crosslinked PVA systems (> 50%).

Druh

O - Ostatní výsledky

CEP obor

JI - Kompositní materiály

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů