The Effect of Antimicrobial Agents on the Stability of Hydrogels

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The Effect of Antimicrobial Agents on the Stability of Hydrogels

Popis výsledku v původním jazyce

This work is focused on the effect of antimicrobial agents on the stability of hydrogels. The aim of the study was the production of new hydrophilic gelling polymer compositions based on acrylic acid copolymer for application in cosmetology and pharmacy, respectively. The effect of the hydrogel modification with bioactive compounds, such as nisin (originating from whey fermentation products) and essential oils of citrus fruit, on physico-chemical and antibacterial properties of the resulting system was investigated. Prepared hydrogels were subjected to accelerated stress test, during which the pH, the viscosity and the concentrate of nisin (by RP-HPLC) was measured. The antimicrobial efficacy test was also carried out. Results showed the addition of nisin decrease pH and viscosity and vice versa the essential oils do not influence these properties. During the stress test the concentration of nisin was decreased similarly in all prepared samples. All tested systems proved significant reduction of microorganisms growth but synergy of nisin and essential oils was found out and it was found to be promising preservative system. ACKNOWLEDGMENTS

Název v anglickém jazyce

The Effect of Antimicrobial Agents on the Stability of Hydrogels

Popis výsledku anglicky

This work is focused on the effect of antimicrobial agents on the stability of hydrogels. The aim of the study was the production of new hydrophilic gelling polymer compositions based on acrylic acid copolymer for application in cosmetology and pharmacy, respectively. The effect of the hydrogel modification with bioactive compounds, such as nisin (originating from whey fermentation products) and essential oils of citrus fruit, on physico-chemical and antibacterial properties of the resulting system was investigated. Prepared hydrogels were subjected to accelerated stress test, during which the pH, the viscosity and the concentrate of nisin (by RP-HPLC) was measured. The antimicrobial efficacy test was also carried out. Results showed the addition of nisin decrease pH and viscosity and vice versa the essential oils do not influence these properties. During the stress test the concentration of nisin was decreased similarly in all prepared samples. All tested systems proved significant reduction of microorganisms growth but synergy of nisin and essential oils was found out and it was found to be promising preservative system. ACKNOWLEDGMENTS

Druh

O - Ostatní výsledky

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů