The Optimization of Method for Preparing Microparticles

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The Optimization of Method for Preparing Microparticles

Popis výsledku v původním jazyce

Alginate is a natural polysaccharide which is obtained from brown algae. Alginates are widely used in food industries. It is also used in pharmaceutical industries as a matrix for the entrapment or encapsulated drugs. Alginate particles can be produced in several ways. One of them is a spray-coagulation method. The particles produced by this method are porous. Calcium chloride solution is used as gelation agent in various concentrations. This study is focused on optimalization of method for preparing alginate particles mainly on their size and shape. Conditions that are changed are flow rate, air pressure, height of needle, concentration of alginate and CaCl2 solution. The shape and a surface of particles is identified from scanning electron microscopy (SEM). Their size is meassured by Mastersizer 3000 laser particle size analyzer. Results showed that changed conditions have an effect on physical properties of particles. The size of particles is decreased with decreasing flow rate, increasing pressure of air and also with more concentrated solution of calcium chloride.

Název v anglickém jazyce

The Optimization of Method for Preparing Microparticles

Popis výsledku anglicky

Alginate is a natural polysaccharide which is obtained from brown algae. Alginates are widely used in food industries. It is also used in pharmaceutical industries as a matrix for the entrapment or encapsulated drugs. Alginate particles can be produced in several ways. One of them is a spray-coagulation method. The particles produced by this method are porous. Calcium chloride solution is used as gelation agent in various concentrations. This study is focused on optimalization of method for preparing alginate particles mainly on their size and shape. Conditions that are changed are flow rate, air pressure, height of needle, concentration of alginate and CaCl2 solution. The shape and a surface of particles is identified from scanning electron microscopy (SEM). Their size is meassured by Mastersizer 3000 laser particle size analyzer. Results showed that changed conditions have an effect on physical properties of particles. The size of particles is decreased with decreasing flow rate, increasing pressure of air and also with more concentrated solution of calcium chloride.

Druh

O - Ostatní výsledky

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

C - Předmět řešení projektu podléhá obchodnímu tajemství (§ 504 Občanského zákoníku), ale název projektu, cíle projektu a u ukončeného nebo zastaveného projektu zhodnocení výsledku řešení projektu (údaje P03, P04, P15, P19, P29, PN8) dodané do CEP, jsou upraveny tak, aby byly zveřejnitelné.