Formation of polymer particles with supercritical CO2: A review

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Formation of polymer particles with supercritical CO2: A review

Popis výsledku v původním jazyce

Recently some particle formation processes and micronization has been increased due to growing concerns regarding health, safety and the environment. The particle formation processes are either solvent-less or use environmentally acceptable solvents such as carbon dioxide have come into favor. Supercritical CO2 (sc CO2) (T > 31.1 oC, P > 7.3 MPa) has been used in pharmaceutical industries to minimize the use of organic solvents and micronize (0.1-5 mm) pharmaceuticals. Control of particle size increases the dissolution rate of drugs into the body. The low viscosity and high diffusivity of scCO2 offer the possibility of novel processing routes for drug delivery. There are several techniques for the particle formation which is used supercritical CO2 either as a solvent, and solution is rapidly expanded (rapid expansion of supercritical solutions, RESS), or as a solute leading to the formation of particles from gas-saturated solutions (PGSS), or as an anti-solvent leading precipitation induced particle formation as in (supercritical anti-solvent (SAS),gas anti-solvent (GAS) solution enhanced dispersion by supercritical fluid (SEDS) and aerosol solvent extraction systems (ASES)). Abstract Template

Název v anglickém jazyce

Formation of polymer particles with supercritical CO2: A review

Popis výsledku anglicky

Recently some particle formation processes and micronization has been increased due to growing concerns regarding health, safety and the environment. The particle formation processes are either solvent-less or use environmentally acceptable solvents such as carbon dioxide have come into favor. Supercritical CO2 (sc CO2) (T > 31.1 oC, P > 7.3 MPa) has been used in pharmaceutical industries to minimize the use of organic solvents and micronize (0.1-5 mm) pharmaceuticals. Control of particle size increases the dissolution rate of drugs into the body. The low viscosity and high diffusivity of scCO2 offer the possibility of novel processing routes for drug delivery. There are several techniques for the particle formation which is used supercritical CO2 either as a solvent, and solution is rapidly expanded (rapid expansion of supercritical solutions, RESS), or as a solute leading to the formation of particles from gas-saturated solutions (PGSS), or as an anti-solvent leading precipitation induced particle formation as in (supercritical anti-solvent (SAS),gas anti-solvent (GAS) solution enhanced dispersion by supercritical fluid (SEDS) and aerosol solvent extraction systems (ASES)). Abstract Template

Druh

O - Ostatní výsledky

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

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Projekt

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Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů