Polylactide-Gadolinium nanoparticles as diagnostic and therapeutic tool

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F18%3A63521626" target="_blank" >RIV/70883521:28610/18:63521626 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Polylactide-Gadolinium nanoparticles as diagnostic and therapeutic tool

Popis výsledku v původním jazyce

Gadolinium (Gd) chelates have been widely used as contrast agent in magnetic resonance imaging (MRI) and neutron capture therapy (NCT). However, the poor selective tissue labelling and localisation provided by conventional molecular Gd chelates have confined their success and limited the application. Encapsulate Gd into nanoparticles can be considered as a method to overcome these limitations. In this regard, polylactic aciddiethylenetriaminopentaacetic acid (DTPA) conjugate was used to develop nanoparticles able to allocate Gd and fluoresceine isothyocianide to enhance MRI and fluorescent contrast, respectively. The Gd-labeled nanoparticles showed the potential as targeting molecular MRI contrast agent for further clinical utilisation.

Název v anglickém jazyce

Polylactide-Gadolinium nanoparticles as diagnostic and therapeutic tool

Popis výsledku anglicky

Gadolinium (Gd) chelates have been widely used as contrast agent in magnetic resonance imaging (MRI) and neutron capture therapy (NCT). However, the poor selective tissue labelling and localisation provided by conventional molecular Gd chelates have confined their success and limited the application. Encapsulate Gd into nanoparticles can be considered as a method to overcome these limitations. In this regard, polylactic aciddiethylenetriaminopentaacetic acid (DTPA) conjugate was used to develop nanoparticles able to allocate Gd and fluoresceine isothyocianide to enhance MRI and fluorescent contrast, respectively. The Gd-labeled nanoparticles showed the potential as targeting molecular MRI contrast agent for further clinical utilisation.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30404 - Biomaterials (as related to medical implants, devices, sensors)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů