Unexpected unique properties of conducting polymers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F23%3A63574198" target="_blank" >RIV/70883521:28610/23:63574198 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Unexpected unique properties of conducting polymers

Popis výsledku v původním jazyce

A large interest is currently growing in the field of combination of synthetic- and bio-polymers resulting in materials with unique properties. In case of conducting polymers, which are especially advantageous as cell-instructive materials, the colloidal particles are important as they are the onlyform of conducting polymers dispersible in aqueous environment. This characteristic makes them especially beneficial for preparation of composite biomaterials. The polyaniline colloidal particles prepared by chemical route are well known and frequently studied; however, we present a green,nature-friendly approach based on enzyme-based polymerization of one of the conducting polymers, polyaniline, which is synthetized via the oxidation of aniline with hydroperoxideactivated horseradish peroxidase and chitosan or poly(vinyl alcohol) as steric stabilizers. The particles prepared in this way prove, except for other properties, the interesting biological properties, mainly immunomodulatory effect. This is the first time the immunomodulatory effect of conducting polymer based colloidal particles was observed. Moreover, the colloidal particles were able to reduce oxidative stress and inhibit the production of reactive oxidation species by neutrophils and inflammatory cytokines by macrophages. The anti-inflammatory effect observed was related to their antioxidant activity, especially in the case of netrophils.

Název v anglickém jazyce

Unexpected unique properties of conducting polymers

Popis výsledku anglicky

A large interest is currently growing in the field of combination of synthetic- and bio-polymers resulting in materials with unique properties. In case of conducting polymers, which are especially advantageous as cell-instructive materials, the colloidal particles are important as they are the onlyform of conducting polymers dispersible in aqueous environment. This characteristic makes them especially beneficial for preparation of composite biomaterials. The polyaniline colloidal particles prepared by chemical route are well known and frequently studied; however, we present a green,nature-friendly approach based on enzyme-based polymerization of one of the conducting polymers, polyaniline, which is synthetized via the oxidation of aniline with hydroperoxideactivated horseradish peroxidase and chitosan or poly(vinyl alcohol) as steric stabilizers. The particles prepared in this way prove, except for other properties, the interesting biological properties, mainly immunomodulatory effect. This is the first time the immunomodulatory effect of conducting polymer based colloidal particles was observed. Moreover, the colloidal particles were able to reduce oxidative stress and inhibit the production of reactive oxidation species by neutrophils and inflammatory cytokines by macrophages. The anti-inflammatory effect observed was related to their antioxidant activity, especially in the case of netrophils.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů