Multiactive hydrogel-based wound dressings

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Multiactive hydrogel-based wound dressings

Popis výsledku v původním jazyce

Open wound belongs to the most common injuries worldwide. The complications caused by insufficient treatment lead to chronic wounds and can have an impact on the quality of life1 . Moreover, the economic impact on health care is significant. To ensure comprehensive treatment, an idea! wound dressing should support all phases of the wound healing process. Le. it should act as antiinflammatory and antimicrobial agent together with possessing good biocompatibility, moisture and skin adhesion2.Here, we have designed conductive chitosan-based wound dressings containing polypyrrole (PPy) crosslinked using nature-derived 2,3-dialdehyde cellulose (DAC). Water-soluble half N-acetylated chitosan (SCN) was used for the hydrogel preparation. Important advantage is that these wound dressings is possible to prepare by simply and low-cost proces. Prepared wound dressing are shown in Fig. 1 a. They offer very good and adaptable skin adhesion (Fig. 1 c ), appropriate mechanical properties and specific conductivity comparable to human tissues (Fig. 1 b ). The polypyrrole particles are homogenously dispersed in the hydrogel network without the formation of aggregates and their concentration can be controlled.

Název v anglickém jazyce

Multiactive hydrogel-based wound dressings

Popis výsledku anglicky

Open wound belongs to the most common injuries worldwide. The complications caused by insufficient treatment lead to chronic wounds and can have an impact on the quality of life1 . Moreover, the economic impact on health care is significant. To ensure comprehensive treatment, an idea! wound dressing should support all phases of the wound healing process. Le. it should act as antiinflammatory and antimicrobial agent together with possessing good biocompatibility, moisture and skin adhesion2.Here, we have designed conductive chitosan-based wound dressings containing polypyrrole (PPy) crosslinked using nature-derived 2,3-dialdehyde cellulose (DAC). Water-soluble half N-acetylated chitosan (SCN) was used for the hydrogel preparation. Important advantage is that these wound dressings is possible to prepare by simply and low-cost proces. Prepared wound dressing are shown in Fig. 1 a. They offer very good and adaptable skin adhesion (Fig. 1 c ), appropriate mechanical properties and specific conductivity comparable to human tissues (Fig. 1 b ). The polypyrrole particles are homogenously dispersed in the hydrogel network without the formation of aggregates and their concentration can be controlled.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů