Smart biopolymer scaffolds based on hyaluronic acid and carbonyl iron microparticles: 3D printing, magneto-responsive, and cytotoxicity study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F24%3A63581518" target="_blank" >RIV/70883521:28610/24:63581518 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/70883521:28110/24:63581518

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acsabm.4c00567" target="_blank" >https://pubs.acs.org/doi/10.1021/acsabm.4c00567</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsabm.4c00567" target="_blank" >10.1021/acsabm.4c00567</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Smart biopolymer scaffolds based on hyaluronic acid and carbonyl iron microparticles: 3D printing, magneto-responsive, and cytotoxicity study

Popis výsledku v původním jazyce

This study deals with utilization of the hyaluronic acid (HA) and carbonyl iron (CI) microparticles to fabricate the magneto-responsive hydrogel scaffolds that can provide triggered functionality upon application of an external magnetic field. The various combinations of the HA and CI were investigated from the rheological and viscoelastic point of view to clearly show promising behavior in connection to 3D printing. Furthermore, the swelling capabilities with water diffusion kinetics were also elucidated. Magneto-responsive performance of bulk hydrogels and their noncytotoxic nature were investigated,, and all hydrogels showed cell viability in the range 75-85%. The 3D printing of such developed systems was successful, and fundamental characterization of the scaffolds morphology (SEM and CT) has been presented. The magnetic activity of the final scaffolds was confirmed at a very low magnetic field strength of 140 kA/m, and such a scaffold also provides very good biocompatibility with NIH/3T3 fibroblasts.

Název v anglickém jazyce

Smart biopolymer scaffolds based on hyaluronic acid and carbonyl iron microparticles: 3D printing, magneto-responsive, and cytotoxicity study

Popis výsledku anglicky

This study deals with utilization of the hyaluronic acid (HA) and carbonyl iron (CI) microparticles to fabricate the magneto-responsive hydrogel scaffolds that can provide triggered functionality upon application of an external magnetic field. The various combinations of the HA and CI were investigated from the rheological and viscoelastic point of view to clearly show promising behavior in connection to 3D printing. Furthermore, the swelling capabilities with water diffusion kinetics were also elucidated. Magneto-responsive performance of bulk hydrogels and their noncytotoxic nature were investigated,, and all hydrogels showed cell viability in the range 75-85%. The 3D printing of such developed systems was successful, and fundamental characterization of the scaffolds morphology (SEM and CT) has been presented. The magnetic activity of the final scaffolds was confirmed at a very low magnetic field strength of 140 kA/m, and such a scaffold also provides very good biocompatibility with NIH/3T3 fibroblasts.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ACS Applied Bio Materials

ISSN

2576-6422

e-ISSN

—

Svazek periodika

7

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

7483-7493

Kód UT WoS článku

001337252100001

EID výsledku v databázi Scopus

2-s2.0-85207869044