Study of Insulin Electrochemical Reaction Mechanism on Modified Ni-Chit/Spce Electrode

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Study of Insulin Electrochemical Reaction Mechanism on Modified Ni-Chit/Spce Electrode

Popis výsledku v původním jazyce

Insulin is the main hormone that regulates the glucose level in blood. Dysfunction in insulin production or action causes a serious disease called diabetes mellitus. Currently the glucose sensors are using for monitoring the course of the disease, but during treating diabetes, it is also necessary to know the concentration of insulin in body fluids. lt offers information about the function of the pancreas and how much insulin was produced. A change in the concentration of glucose in the blood is the body&apos;s reaction to low insulin concentration or low sensitivity of cells to the presence of insulin.The insulin detection could be provided by immunoassay, chromatographic methods, electrochemical sensors etc. Among them electrochemical sensors display various advantages such as fast response, simple preparation, inexpensive instruments, and easy-to-use device. Modification of sensors working electrode improves electroanalytical properties of studied sensors. Various metal nanoparticles, metal oxide nanoparticles, and carbon nanomaterials are used for sensors modification. These nanomaterials are frequently fixed on the surface of electrode by using polymer film. Among polymer materials Nafion, chitosan, polypyrrole, and polyaniline are the most often used materials.Herein, we are focused on development of electrochemical sensor based on the nickel nanoparticles immobilised by chitosan film on the surface of screen printed carbon electrode (Ni-chit/SPCE). The mechanism of electrochemical reaction plays key role in the insulin electrochemical detection. There is the possibility to improve electrode material taking into consideration reaction mechanism and rate determining step. For studying of reaction mechanism was used cyclic voltammetry.

Název v anglickém jazyce

Study of Insulin Electrochemical Reaction Mechanism on Modified Ni-Chit/Spce Electrode

Popis výsledku anglicky

Insulin is the main hormone that regulates the glucose level in blood. Dysfunction in insulin production or action causes a serious disease called diabetes mellitus. Currently the glucose sensors are using for monitoring the course of the disease, but during treating diabetes, it is also necessary to know the concentration of insulin in body fluids. lt offers information about the function of the pancreas and how much insulin was produced. A change in the concentration of glucose in the blood is the body&apos;s reaction to low insulin concentration or low sensitivity of cells to the presence of insulin.The insulin detection could be provided by immunoassay, chromatographic methods, electrochemical sensors etc. Among them electrochemical sensors display various advantages such as fast response, simple preparation, inexpensive instruments, and easy-to-use device. Modification of sensors working electrode improves electroanalytical properties of studied sensors. Various metal nanoparticles, metal oxide nanoparticles, and carbon nanomaterials are used for sensors modification. These nanomaterials are frequently fixed on the surface of electrode by using polymer film. Among polymer materials Nafion, chitosan, polypyrrole, and polyaniline are the most often used materials.Herein, we are focused on development of electrochemical sensor based on the nickel nanoparticles immobilised by chitosan film on the surface of screen printed carbon electrode (Ni-chit/SPCE). The mechanism of electrochemical reaction plays key role in the insulin electrochemical detection. There is the possibility to improve electrode material taking into consideration reaction mechanism and rate determining step. For studying of reaction mechanism was used cyclic voltammetry.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů