Development of Injectable Chitosan-Based Hydrogels

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F24%3A63588578" target="_blank" >RIV/70883521:28610/24:63588578 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Development of Injectable Chitosan-Based Hydrogels

Popis výsledku v původním jazyce

In the past decade, shear-thinning hydrogels have been intensively investigated in various biomedical applications, highlighting their potential for drug delivery and tissue engineering. These hydrogels exhibit efficacy due to their unique properties based on reversible and dynamic chemistry. During injection, they can liquify under shear stress and subsequently restore to their original state upon stress removal. This characteristic brings numerous advantages compared to traditional biomaterials, enabling targeted delivery using a syringe, without requiring invasive surgical procedures, thereby facilitating tissue regeneration and wound healing on site. In this study, we have prepared injectable hydrogels from partially reacetylated chitosan, which is water-soluble without needing an acidic environment, unlike conventional chitosan. Dialdehyde cellulose (DAC), which is an environmentally friendly cellulose derivative of low toxicity, was employed for hydrogel crosslinking. The resulting injectable hydrogels are non-cytotoxic, biocompatible, and exhibit shear-thinning properties. The prepared shear-thinning hydrogels represent an interesting possibility for the development of advanced injectable biomaterials and composites in the future, especially in the field of wound healing and anti-inflammatory applications.

Název v anglickém jazyce

Development of Injectable Chitosan-Based Hydrogels

Popis výsledku anglicky

In the past decade, shear-thinning hydrogels have been intensively investigated in various biomedical applications, highlighting their potential for drug delivery and tissue engineering. These hydrogels exhibit efficacy due to their unique properties based on reversible and dynamic chemistry. During injection, they can liquify under shear stress and subsequently restore to their original state upon stress removal. This characteristic brings numerous advantages compared to traditional biomaterials, enabling targeted delivery using a syringe, without requiring invasive surgical procedures, thereby facilitating tissue regeneration and wound healing on site. In this study, we have prepared injectable hydrogels from partially reacetylated chitosan, which is water-soluble without needing an acidic environment, unlike conventional chitosan. Dialdehyde cellulose (DAC), which is an environmentally friendly cellulose derivative of low toxicity, was employed for hydrogel crosslinking. The resulting injectable hydrogels are non-cytotoxic, biocompatible, and exhibit shear-thinning properties. The prepared shear-thinning hydrogels represent an interesting possibility for the development of advanced injectable biomaterials and composites in the future, especially in the field of wound healing and anti-inflammatory applications.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30404 - Biomaterials (as related to medical implants, devices, sensors)

Projekt

<a href="/cs/project/GA24-11534S" target="_blank" >GA24-11534S: Vodivé (bio)polymerní kompozity s kovalentně vázaným polypyrrolem pro biomedicínské aplikace</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů