Pediococcus pentosaceus-based probiotic bacterial cellulose: A novel biomaterial for healthcare applications

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Pediococcus pentosaceus-based probiotic bacterial cellulose: A novel biomaterial for healthcare applications

Popis výsledku v původním jazyce

Biopolymers with antimicrobial properties have gained attention in biomedical fields for producing different healthcare materials, viz., implants, scaffolds, etc. Bacterial cellulose (BC), in spite of being a versatile biopolymer with a wide range of applications in healthcare, does not have any innate antimicrobial properties. In this work, probiotic bacterial cellulose (PBC) is synthesized by co-culturing BC producing bacteria, Komagataeibacter xylinus (Kx) and a probiotic bacterial strain, Pediococcus pentosaceus (Pp), to integrate the extracellular antimicrobial compounds released by Pp within the BC mat. The newly synthesized biopolymer/biomaterial (PBC) having antimicrobial properties within it, denoted as ‘PBC_Pp’. This material is tested against gram-positive bacteria Staphylococcus aureus (S. aureus) and gram-negative bacteria Escherichia coli (E. coli). PBC_Pp has shown distinct inhibition zones in the case of both E. coli and S. aureus. Moreover, PBC_Pp has shown its native chemical, thermal and morphological properties as BC. The newly synthesized PBC_Pp is revealing quite a good antimicrobial property including its inherent polymer properties of BC. The co-culture of bacterial strain (Kx and Pp) in a specific growth medium, resolves to develop some innovative biopolymer (PBC_Pp) which could be implemented for the preparation of various healthcare applications in the form of hydrogels, implants or scaffolds.

Název v anglickém jazyce

Pediococcus pentosaceus-based probiotic bacterial cellulose: A novel biomaterial for healthcare applications

Popis výsledku anglicky

Biopolymers with antimicrobial properties have gained attention in biomedical fields for producing different healthcare materials, viz., implants, scaffolds, etc. Bacterial cellulose (BC), in spite of being a versatile biopolymer with a wide range of applications in healthcare, does not have any innate antimicrobial properties. In this work, probiotic bacterial cellulose (PBC) is synthesized by co-culturing BC producing bacteria, Komagataeibacter xylinus (Kx) and a probiotic bacterial strain, Pediococcus pentosaceus (Pp), to integrate the extracellular antimicrobial compounds released by Pp within the BC mat. The newly synthesized biopolymer/biomaterial (PBC) having antimicrobial properties within it, denoted as ‘PBC_Pp’. This material is tested against gram-positive bacteria Staphylococcus aureus (S. aureus) and gram-negative bacteria Escherichia coli (E. coli). PBC_Pp has shown distinct inhibition zones in the case of both E. coli and S. aureus. Moreover, PBC_Pp has shown its native chemical, thermal and morphological properties as BC. The newly synthesized PBC_Pp is revealing quite a good antimicrobial property including its inherent polymer properties of BC. The co-culture of bacterial strain (Kx and Pp) in a specific growth medium, resolves to develop some innovative biopolymer (PBC_Pp) which could be implemented for the preparation of various healthcare applications in the form of hydrogels, implants or scaffolds.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů