Cooling of the auditory cortex modifies neuronal activity in the inferior colliculus in rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F71226401%3A_____%2F15%3A%231006872" target="_blank" >RIV/71226401:_____/15:#1006872 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/16:00458702 RIV/00216208:11120/16:43910460 RIV/71226401:_____/16:N0000195

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.heares.2015.10.021" target="_blank" >http://dx.doi.org/10.1016/j.heares.2015.10.021</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.heares.2015.10.021" target="_blank" >10.1016/j.heares.2015.10.021</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cooling of the auditory cortex modifies neuronal activity in the inferior colliculus in rats

Popis výsledku v původním jazyce

There are powerful pathways descending from the auditory cortex (AC) to the inferior colliculus (IC), yet their function is not fully understood. The aim of this study is to examine the effects of a reversible cortical inactivation, achieved by cooling of the AC, on the responses of neurons in the rat IC. Extracellular single-unit or multi-unit activity was recorded in the IC of anaesthetized rats with a 16-channel multielectrode probe introduced along the IC dorso-ventral axis through the dorsal cortex(DCIC) to the central nucleus of the IC (CIC). Cooling of the AC produced an increase in spontaneous activity and magnitude of the sound-evoked response in 47% of the IC neurons. Maximal changes in the neuronal activity were observed in the DCIC and thecentral part of the CIC. The final segments of the sustained responses to 60 ms stimuli and the off responses were more affected than the onset segments. Inactivation of the AC resulted in a suppression of the post-excitatory inhibition

Název v anglickém jazyce

Cooling of the auditory cortex modifies neuronal activity in the inferior colliculus in rats

Popis výsledku anglicky

There are powerful pathways descending from the auditory cortex (AC) to the inferior colliculus (IC), yet their function is not fully understood. The aim of this study is to examine the effects of a reversible cortical inactivation, achieved by cooling of the AC, on the responses of neurons in the rat IC. Extracellular single-unit or multi-unit activity was recorded in the IC of anaesthetized rats with a 16-channel multielectrode probe introduced along the IC dorso-ventral axis through the dorsal cortex(DCIC) to the central nucleus of the IC (CIC). Cooling of the AC produced an increase in spontaneous activity and magnitude of the sound-evoked response in 47% of the IC neurons. Maximal changes in the neuronal activity were observed in the DCIC and thecentral part of the CIC. The final segments of the sustained responses to 60 ms stimuli and the off responses were more affected than the onset segments. Inactivation of the AC resulted in a suppression of the post-excitatory inhibition

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Hearing Research

ISSN

0378-5955

e-ISSN

—

Svazek periodika

332

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

7-16

Kód UT WoS článku

000371944200002

EID výsledku v databázi Scopus

2-s2.0-84949845281