Ochratoxin A: Developmental and reproductive toxicity - an overview

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F13%3A00010261" target="_blank" >RIV/75010330:_____/13:00010261 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62690094:18470/13:50001978 RIV/00216208:11160/13:10282178

Výsledek na webu

<a href="http://dx.doi.org/10.1002/bdrb.21091" target="_blank" >http://dx.doi.org/10.1002/bdrb.21091</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/bdrb.21091" target="_blank" >10.1002/bdrb.21091</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Ochratoxin A: Developmental and reproductive toxicity - an overview

Popis výsledku v původním jazyce

Ochratoxin A (OTA) is nephrotoxic, hepatotoxic, reprotoxic, embryotoxic, teratogenic, neurotoxic, immunotoxic, and carcinogenic for laboratory and farm animals. Male and female reproductive health has deteriorated in many countries during the last few decades. A number of toxins in environment are suspected to affect reproductive system in male and female. OTA is one of them. OTA has been found to be teratogenic in several animal models including rat, mouse, hamster, quail, and chick, with reduced birthweight and craniofacial abnormalities being the most common signs. The presence of OTA also results in congenital defects in the fetus. Neither the potential of OTA to cause malformations in human nor its teratogenic mode of action is known. Exposure toOTA leads to increased embryo lethality manifested as resorptions or dead fetuses. The mechanism of OTA transfer across human placenta (e.g., which transporters are involved in the transfer mechanism) is not fully understood. Some of the

Název v anglickém jazyce

Ochratoxin A: Developmental and reproductive toxicity - an overview

Popis výsledku anglicky

Ochratoxin A (OTA) is nephrotoxic, hepatotoxic, reprotoxic, embryotoxic, teratogenic, neurotoxic, immunotoxic, and carcinogenic for laboratory and farm animals. Male and female reproductive health has deteriorated in many countries during the last few decades. A number of toxins in environment are suspected to affect reproductive system in male and female. OTA is one of them. OTA has been found to be teratogenic in several animal models including rat, mouse, hamster, quail, and chick, with reduced birthweight and craniofacial abnormalities being the most common signs. The presence of OTA also results in congenital defects in the fetus. Neither the potential of OTA to cause malformations in human nor its teratogenic mode of action is known. Exposure toOTA leads to increased embryo lethality manifested as resorptions or dead fetuses. The mechanism of OTA transfer across human placenta (e.g., which transporters are involved in the transfer mechanism) is not fully understood. Some of the

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

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Projekt

<a href="/cs/project/NT12051" target="_blank" >NT12051: Ochratoxin A - hodnocení zdravotního rizika pro vybrané populační skupiny v ČR</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Birth Defects Research Part B: Developmental and Reproductive Toxicology

ISSN

1542-9733

e-ISSN

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Svazek periodika

98

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

493-502

Kód UT WoS článku

000331142300005

EID výsledku v databázi Scopus

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