Excess mortality after hip fracture in elderly persons from Europe and the USA: the CHANCES project

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F17%3A00011695" target="_blank" >RIV/75010330:_____/17:00011695 - isvavai.cz</a>

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1111/joim.12586/abstract;jsessionid=BE72A1637FBF8B4F28B6A44A2457C293.f03t02" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/joim.12586/abstract;jsessionid=BE72A1637FBF8B4F28B6A44A2457C293.f03t02</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/joim.12586" target="_blank" >10.1111/joim.12586</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Excess mortality after hip fracture in elderly persons from Europe and the USA: the CHANCES project

Popis výsledku v původním jazyce

Background Hip fractures are associated with diminished quality of life and survival especially amongst the elderly. Objective All-cause mortality after hip fracture was investigated to assess its magnitude. Methods A total of 122 808 participants from eight cohorts in Europe and the USA were followed up for a mean of 12.6 years, accumulating 4273 incident hip fractures and 27 999 deaths. Incident hip fractures were assessed through telephone interviews/questionnaires or national inpatient/fracture registries, and causes of death were verified with death certificates. Cox proportional hazards models and the time-dependent variable methodology were used to assess the association between hip fracture and mortality and its magnitude at different time intervals after the injury in each cohort. We obtained the effect estimates through a random-effects meta-analysis. Results Hip fracture was positively associated with increased all-cause mortality, the hazard ratio (HR) in the fully adjusted model was 2.12, 95% confidence interval (CI) 1.76-2.57, after adjusting for potential confounders. This association was stronger amongst men [HR: 2.39, 95% CI: 1.72-3.31] than amongst women [HR: 1.92, 95% CI: 1.54-2.39], although this difference was not significant. Mortality was higher during the first year after the hip fracture [HR: 2.78, 95% CI: 2.12-3.64], but it remained elevated without major fluctuations after longer time since hip fracture [HR (95% CI): 1.89 (1.50-2.37) after 1-4 years, 2.15 (1.81-2.55) after 4-8 years, 1.79 (1.57-2.05) after 8 or more years]. Conclusion In this large population-based sample of older persons across eight cohorts, hip fracture was associated with excess short- and long-term all-cause mortality in both sexes.

Název v anglickém jazyce

Excess mortality after hip fracture in elderly persons from Europe and the USA: the CHANCES project

Popis výsledku anglicky

Background Hip fractures are associated with diminished quality of life and survival especially amongst the elderly. Objective All-cause mortality after hip fracture was investigated to assess its magnitude. Methods A total of 122 808 participants from eight cohorts in Europe and the USA were followed up for a mean of 12.6 years, accumulating 4273 incident hip fractures and 27 999 deaths. Incident hip fractures were assessed through telephone interviews/questionnaires or national inpatient/fracture registries, and causes of death were verified with death certificates. Cox proportional hazards models and the time-dependent variable methodology were used to assess the association between hip fracture and mortality and its magnitude at different time intervals after the injury in each cohort. We obtained the effect estimates through a random-effects meta-analysis. Results Hip fracture was positively associated with increased all-cause mortality, the hazard ratio (HR) in the fully adjusted model was 2.12, 95% confidence interval (CI) 1.76-2.57, after adjusting for potential confounders. This association was stronger amongst men [HR: 2.39, 95% CI: 1.72-3.31] than amongst women [HR: 1.92, 95% CI: 1.54-2.39], although this difference was not significant. Mortality was higher during the first year after the hip fracture [HR: 2.78, 95% CI: 2.12-3.64], but it remained elevated without major fluctuations after longer time since hip fracture [HR (95% CI): 1.89 (1.50-2.37) after 1-4 years, 2.15 (1.81-2.55) after 4-8 years, 1.79 (1.57-2.05) after 8 or more years]. Conclusion In this large population-based sample of older persons across eight cohorts, hip fracture was associated with excess short- and long-term all-cause mortality in both sexes.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30304 - Public and environmental health

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Internal Medicine

ISSN

0954-6820

e-ISSN

1365-2796

Svazek periodika

281

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

300-310

Kód UT WoS článku

000394893800007

EID výsledku v databázi Scopus

2-s2.0-85012979808