Exposure to mixed phthalates in Czech preschool and school children

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F19%3A00012703" target="_blank" >RIV/75010330:_____/19:00012703 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/19:43918388

Výsledek na webu

<a href="https://link.springer.com/article/10.1007%2Fs00244-019-00645-6" target="_blank" >https://link.springer.com/article/10.1007%2Fs00244-019-00645-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00244-019-00645-6" target="_blank" >10.1007/s00244-019-00645-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Exposure to mixed phthalates in Czech preschool and school children

Popis výsledku v původním jazyce

Knowledge of population exposure to phthalates based on the urinary metabolite levels is of the highest importance for health risk assessment. Such data are scarce in the Czech population. In the study conducted in 2016, six urinary phthalate metabolites were analysed in a total of 370 first morning urine samples of healthy children aged 5 and 9 years, namely mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (5OH-MEHP), mono(2-ethyl-5-oxohexyl) phthalate (5oxo-MEHP), mono-benzyl phthalate (MBzP), mono-iso-butyl phthalate (MiBP), and mono-n-butyl phthalate (MnBP). The two latter mono-butyl phthalate isoforms dominated among all samples with geometric means of 63.0 mu g/L (MnBP) and 44.1 mu g/L (MiBP), followed by 5OH-MEHP (20.6 mu g/L), 5oxo-MEHP (12.9 mu g/L), MBzP (3.65 mu g/L), and MEHP (2.31 mu g/L). Daily intake (DI) of the parent phthalates was estimated using the creatinine-based model. The highest DI values were found for di-n-butyl phthalate (DnBP) (median 2.5 mu g/kg bw/day; 95th percentile 7.8 mu g/kg bw/day) and di-2-ethylhexyl phthalate (DEHP) (median 2.3 mu g/kg bw/day; 95th percentile 8.9 mu g/kg bw/day) in 5-year-old children. The tolerable daily intake (TDI) set by the European Food Safety Authority (EFSA) was exceeded in case of DnBP (in 1% of 9-year-olds and in 3% of 5-year-olds). Exposure risk was assessed based on hazard quotients calculation and cumulative approach for similar health effect. The combined exposure to four phthalates expressed by hazard index (HI) for reprotoxicity revealed exceeding of HI threshold in 14% of 5-year-olds and in 9% of 9-year-olds. These findings strongly support the need to reduce the burden of children by phthalates.

Název v anglickém jazyce

Exposure to mixed phthalates in Czech preschool and school children

Popis výsledku anglicky

Knowledge of population exposure to phthalates based on the urinary metabolite levels is of the highest importance for health risk assessment. Such data are scarce in the Czech population. In the study conducted in 2016, six urinary phthalate metabolites were analysed in a total of 370 first morning urine samples of healthy children aged 5 and 9 years, namely mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (5OH-MEHP), mono(2-ethyl-5-oxohexyl) phthalate (5oxo-MEHP), mono-benzyl phthalate (MBzP), mono-iso-butyl phthalate (MiBP), and mono-n-butyl phthalate (MnBP). The two latter mono-butyl phthalate isoforms dominated among all samples with geometric means of 63.0 mu g/L (MnBP) and 44.1 mu g/L (MiBP), followed by 5OH-MEHP (20.6 mu g/L), 5oxo-MEHP (12.9 mu g/L), MBzP (3.65 mu g/L), and MEHP (2.31 mu g/L). Daily intake (DI) of the parent phthalates was estimated using the creatinine-based model. The highest DI values were found for di-n-butyl phthalate (DnBP) (median 2.5 mu g/kg bw/day; 95th percentile 7.8 mu g/kg bw/day) and di-2-ethylhexyl phthalate (DEHP) (median 2.3 mu g/kg bw/day; 95th percentile 8.9 mu g/kg bw/day) in 5-year-old children. The tolerable daily intake (TDI) set by the European Food Safety Authority (EFSA) was exceeded in case of DnBP (in 1% of 9-year-olds and in 3% of 5-year-olds). Exposure risk was assessed based on hazard quotients calculation and cumulative approach for similar health effect. The combined exposure to four phthalates expressed by hazard index (HI) for reprotoxicity revealed exceeding of HI threshold in 14% of 5-year-olds and in 9% of 9-year-olds. These findings strongly support the need to reduce the burden of children by phthalates.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30304 - Public and environmental health

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Archives of Environmental Contamination and Toxicology

ISSN

0090-4341

e-ISSN

1432-0703

Svazek periodika

77

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

471-479

Kód UT WoS článku

000490600200001

EID výsledku v databázi Scopus

2-s2.0-85071517628