The Arg753Gln polymorphism of Toll-like receptor 2 has a lower occurrence in patients with syphilis, suggesting its protective effect in Czech and Slovak individuals

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F21%3A00013412" target="_blank" >RIV/75010330:_____/21:00013412 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/21:10420375 RIV/00216224:14110/21:00120100

Výsledek na webu

<a href="https://iai.asm.org/content/89/1/e00503-20.abstract" target="_blank" >https://iai.asm.org/content/89/1/e00503-20.abstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1128/IAI.00503-20" target="_blank" >10.1128/IAI.00503-20</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The Arg753Gln polymorphism of Toll-like receptor 2 has a lower occurrence in patients with syphilis, suggesting its protective effect in Czech and Slovak individuals

Popis výsledku v původním jazyce

Syphilis is a bacterial infection caused by Treponema pallidum subsp. pallidum. Infection with T. pallidum subsp. pallidum and its dissemination lead to the synthesis of proinflammatory cytokines triggered by the interaction of bacterial lipoproteins with Toll-like receptor 2 (TLR2). TLR2 contains several nonsynonymous single-nucleotide polymorphisms that may impact the activation of its signaling cascade and alter the responsiveness to, or the course of, various infectious diseases, including those caused by pathogenic spirochetes. To investigate whether TLR2 polymorphism may influence susceptibility to syphilis, 221 healthy individuals with no history of syphilis (controls) and 137 patients diagnosed with syphilis (cases) were screened for the presence of the Arg753Gln polymorphism in the TLR2 gene (2258G -> A; rs5743708). The Arg753Gln variant occurs at a significantly lower frequency in syphilis patients (4 of 137 [3%]) than in controls (24 of 221 [10.9%]). These data suggest that TLR2 Arg753Gln may protect from the development of syphilis due to reduced signaling.

Název v anglickém jazyce

The Arg753Gln polymorphism of Toll-like receptor 2 has a lower occurrence in patients with syphilis, suggesting its protective effect in Czech and Slovak individuals

Popis výsledku anglicky

Syphilis is a bacterial infection caused by Treponema pallidum subsp. pallidum. Infection with T. pallidum subsp. pallidum and its dissemination lead to the synthesis of proinflammatory cytokines triggered by the interaction of bacterial lipoproteins with Toll-like receptor 2 (TLR2). TLR2 contains several nonsynonymous single-nucleotide polymorphisms that may impact the activation of its signaling cascade and alter the responsiveness to, or the course of, various infectious diseases, including those caused by pathogenic spirochetes. To investigate whether TLR2 polymorphism may influence susceptibility to syphilis, 221 healthy individuals with no history of syphilis (controls) and 137 patients diagnosed with syphilis (cases) were screened for the presence of the Arg753Gln polymorphism in the TLR2 gene (2258G -> A; rs5743708). The Arg753Gln variant occurs at a significantly lower frequency in syphilis patients (4 of 137 [3%]) than in controls (24 of 221 [10.9%]). These data suggest that TLR2 Arg753Gln may protect from the development of syphilis due to reduced signaling.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30303 - Infectious Diseases

Projekt

<a href="/cs/project/NV17-31333A" target="_blank" >NV17-31333A: Vývoj nového typovacího systému pro původce syfilis, Treponema pallidum subsp. pallidum, zaměřeného na proteomické rozdíly</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Infection and Immunity

ISSN

0019-9567

e-ISSN

1098-5522

Svazek periodika

89

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

e00503-20

Kód UT WoS článku

000600550700003

EID výsledku v databázi Scopus

2-s2.0-85098603294